Gene
ptger4c
- ID
- ZDB-GENE-070705-128
- Name
- prostaglandin E receptor 4 (subtype EP4) c
- Symbol
- ptger4c Nomenclature History
- Previous Names
-
- PRS6 (1)
- si:ch211-234e14.2
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables prostaglandin E receptor activity. Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; cellular response to prostaglandin E stimulus; and negative regulation of inflammatory response. Predicted to be active in plasma membrane. Is expressed in brain; intestine; and ovarian follicle stage III. Human ortholog(s) of this gene implicated in ankylosing spondylitis; arteriosclerosis; and ulcerative colitis. Orthologous to human PTGER4 (prostaglandin E receptor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Prostanoid EP4 receptor | Prostanoid receptor |
|---|---|---|---|---|---|---|
| UniProtKB:S6B1G5 | InterPro | 486 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptger4c-201
(1)
|
Ensembl | 1,602 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-234E14 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001281996 (1) | 1488 nt | ||
| Genomic | GenBank:BX296556 (1) | 181230 nt | ||
| Polypeptide | UniProtKB:S6B1G5 (1) | 486 aa |
- Tang, H., Liu, Y., Li, J., Yin, Y., Li, G., Chen, Y., Li, S., Zhang, Y., Lin, H., Liu, X., Cheng, C.H. (2016) Gene knockout of nuclear progesterone receptor provides insights into the regulation of ovulation by LH signaling in zebrafish. Scientific Reports. 6:28545
- Guo, T.C., Gamil, A.A., Koenig, M., Evensen, Ø. (2015) Sequence Analysis and Identification of New Isoform of EP4 Receptors in Different Atlantic Salmon Tissues (Salmo salar L.) and Its Role in PGE2 Induced Immunomodulation In Vitro. PLoS One. 10:e0120483
- Tsuge, K., Iwasaki, R., Morimoto, K., Inazumi, T., Kawahara, O., Kawahara, A., Tsuchiya, S., and Sugimoto, Y. (2013) Molecular and pharmacological characterization of zebrafish 'relaxant' prostanoid receptors. Biochemical and Biophysical Research Communications. 436(4):685-90
1 - 3 of 3
Show