Gene

wrn

ID
ZDB-GENE-070702-2
Name
WRN RecQ like helicase
Symbol
wrn Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to enable 3'-5' DNA helicase activity and four-way junction helicase activity. Acts upstream of or within bone growth. Predicted to be active in chromosome; cytoplasm; and nucleoplasm. Used to study Werner syndrome. Human ortholog(s) of this gene implicated in Werner syndrome; breast cancer; coronary artery disease (multiple); diffuse scleroderma; and senile cataract. Orthologous to human WRN (WRN RecQ like helicase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Tian et al., 2022
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With wrn Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Werner syndrome Alliance Werner syndrome 277700
1 - 1 of 1
Associated With wrn Via Experimental Models
Human Disease Fish Conditions Citations
Werner syndrome wrnsa34829/sa34829 standard conditions Tian et al., 2022
1 - 1 of 1
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001650 Helicase, C-terminal domain-like
Domain IPR002121 HRDC domain
Domain IPR002562 3'-5' exonuclease domain
Domain IPR011545 DEAD/DEAH box helicase domain
Domain IPR014001 Helicase superfamily 1/2, ATP-binding domain
1 - 5 of 16 Show all
Domain Details Per Protein
Protein Additional Resources Length 3'-5' exonuclease domain ATP-dependent DNA helicase RecQ, zinc-binding domain DEAD/DEAH box helicase domain DNA helicase, ATP-dependent, RecQ type Helicase, C-terminal domain-like Helicase Helix-turn-helix domain Helicase superfamily 1/2, ATP-binding domain HRDC domain HRDC domain superfamily HRDC-like superfamily P-loop containing nucleoside triphosphate hydrolase Ribonuclease H-like superfamily Ribonuclease H superfamily RQC domain Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:A0A8M3AV58 InterPro 1387
UniProtKB:A0A0R4IT14 InterPro 1387
UniProtKB:A0AB32TWV4 InterPro 1274
1 - 3 of 3
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA wrn-201 (1)
Ensembl
Ensembl 4,164 nt
ZFIN BLAST
mRNA wrn-202 (1)
Ensembl
Ensembl 4,714 nt
ZFIN BLAST
mRNA wrn-203 (1)
Ensembl
Ensembl 4,311 nt
ZFIN BLAST
1 - 3 of 3
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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