Gene
fadd
- ID
- ZDB-GENE-070606-3
- Name
- Fas (tnfrsf6)-associated via death domain
- Symbol
- fadd Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable caspase binding activity and death receptor binding activity. Acts upstream of or within positive regulation of apoptotic process. Predicted to be located in cytoplasm. Predicted to be part of CD95 death-inducing signaling complex. Is expressed in several structures, including axis; brain; germ ring; immature eye; and ventral mandibular arch. Human ortholog(s) of this gene implicated in immunodeficiency 90 and leukemia. Orthologous to human FADD (Fas associated via death domain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Serbanovic-Canic et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 90 | Alliance | Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction | 613759 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Death domain | Death effector domain | Death-like domain superfamily | FAS-associated death domain protein |
|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IXF0 | InterPro | 192 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available