Gene
g6pd
- ID
- ZDB-GENE-070508-4
- Name
- glucose-6-phosphate dehydrogenase
- Symbol
- g6pd Nomenclature History
- Previous Names
-
- fj78b06
- si:dkey-90a13.8
- wu:fj78b06
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Enables UDP-glucose 6-dehydrogenase activity and glucose-6-phosphate dehydrogenase activity. Acts upstream of or within epiboly and vascular associated smooth muscle cell differentiation. Predicted to be active in cytosol. Used to study hemolytic anemia. Human ortholog(s) of this gene implicated in anemia (multiple); cerebrovascular disease; diabetes mellitus; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa5035 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11949 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19319 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa24272 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| uto70 | Allele with one delins | Unknown | Unknown | CRISPR | |
| zf3820 | Allele with one delins | Unknown | Unknown | not specified |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-g6pd | Hwang et al., 2018 | |
| CRISPR2-g6pd | Martínez-Navarro et al., 2020 | |
| CRISPR3-g6pd | Facchinello et al., 2022 | |
| CRISPR4-g6pd | (2) | |
| CRISPR5-g6pd | Tan et al., 2024 | |
| CRISPR6-g6pd | Tan et al., 2024 | |
| MO1-g6pd | N/A | (3) |
| MO2-g6pd | N/A | (3) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nonspherocytic hemolytic anemia 1 | Alliance | Anemia, congenital, nonspherocytic hemolytic, 1, G6PD deficient | 300908 |
| {Resistance to malaria due to G6PD deficiency} | 611162 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| hemolytic anemia | AB + CRISPR1-g6pd | standard conditions | Hwang et al., 2018 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR019796 | Glucose-6-phosphate dehydrogenase, active site |
| Domain | IPR022674 | Glucose-6-phosphate dehydrogenase, NAD-binding |
| Domain | IPR022675 | Glucose-6-phosphate dehydrogenase, C-terminal |
| Family | IPR001282 | Glucose-6-phosphate dehydrogenase |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Glucose-6-phosphate dehydrogenase | Glucose-6-phosphate dehydrogenase, active site | Glucose-6-phosphate dehydrogenase, C-terminal | Glucose-6-phosphate dehydrogenase, NAD-binding | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PWR3 | InterPro | 513 | |||||
| UniProtKB:A0A8M9PDT5 | InterPro | 523 | |||||
| UniProtKB:A0A8M2B959 | InterPro | 534 | |||||
| UniProtKB:E7FDY7 | InterPro | 513 | |||||
| UniProtKB:A0A8M3AY75 | InterPro | 528 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-90A13 | ZFIN Curated Data | |
| Encodes | EST | fj78b06 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021469916 (1) | 4264 nt | ||
| Genomic | GenBank:BX897727 (1) | 236277 nt | ||
| Polypeptide | UniProtKB:A0A8M2B959 (1) | 534 aa |
- Noble, A.R., Masek, M., Hofmann, C., Cuoco, A., Rusterholz, T.D.S., Özkoc, H., Greter, N.R., Phelps, I.G., Vladimirov, N., Kollmorgen, S., Stoeckli, E., Bachmann-Gagescu, R. (2024) Shared and unique consequences of Joubert Syndrome gene dysfunction on the zebrafish central nervous system. Biology Open. 13(11):
- Tan, V.W.T., Salmi, T.M., Karamalakis, A.P., Gillespie, A., Ong, A.J.S., Balic, J.J., Chan, Y.C., Bladen, C.E., Brown, K.K., Dawson, M.A., Cox, A.G. (2024) SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway. Developmental Cell. 59(7):898-910.e6
- Zang, X., Wang, Y., Han, C., Cui, L., Liu, H., Tian, S., Liu, K., Li, P., Sun, C., Xia, Q., Zhang, Y. (2024) 2-Acetamidophenol (2-AAP) Suppresses the Progression of Atherosclerosis by Alleviating Hyperlipidemia and Attenuating the Ferroptosis Pathway. Marine drugs. 22(11):
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- Choi, S.S.A., Chan, H.H., Chan, C.M., Wang, X., Webb, S.E., Leung, K.W., Tsim, K.W.K., Miller, A.L. (2022) Neuromasts and Olfactory Organs of Zebrafish Larvae Represent Possible Sites of SARS-CoV-2 Pseudovirus Host Cell Entry. Journal of virology. 96(24):e0141822
- Facchinello, N., Astone, M., Audano, M., Oberkersch, R.E., Spizzotin, M., Calura, E., Marques, M., Crisan, M., Mitro, N., Santoro, M.M. (2022) Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition. Nature metabolism. 4:123-140
- Kamoshita, M., Kumar, R., Anteghini, M., Kunze, M., Islinger, M., Martins Dos Santos, V., Schrader, M. (2022) Insights Into the Peroxisomal Protein Inventory of Zebrafish. Frontiers in Physiology. 13:822509
- Masek, M., Etard, C., Hofmann, C., Hülsmeier, A.J., Zang, J., Takamiya, M., Gesemann, M., Neuhauss, S.C.F., Hornemann, T., Strähle, U., Bachmann-Gagescu, R. (2022) Loss of the Bardet-Biedl protein Bbs1 alters photoreceptor outer segment protein and lipid composition. Nature communications. 13:1282
- Pagán, A.J., Lee, L.J., Edwards-Hicks, J., Moens, C.B., Tobin, D.M., Busch-Nentwich, E.M., Pearce, E.L., Ramakrishnan, L. (2022) mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity. Cell. 185(20):3720-3738.e13
- Tsakoumis, E., Ahi, E.P., Schmitz, M. (2022) Impaired leptin signaling causes subfertility in female zebrafish. Molecular and Cellular Endocrinology. 546:111595
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