Gene
mhc1zca
- ID
- ZDB-GENE-070424-4
- Name
- major histocompatibility complex class I ZCA
- Symbol
- mhc1zca Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to be involved in immune response. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in gill. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); bone marrow cancer (multiple); eye disease (multiple); and liver disease (multiple). Orthologous to several human genes including AZGP1 (alpha-2-glycoprotein 1, zinc-binding); HFE (homeostatic iron regulator); and HLA-A (major histocompatibility complex, class I, A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Dirscherl et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003006 | Immunoglobulin/major histocompatibility complex, conserved site |
| Domain | IPR001039 | MHC class I alpha chain, alpha1 alpha2 domains |
| Domain | IPR003597 | Immunoglobulin C1-set |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR011161 | MHC class I-like antigen recognition-like |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Antigen-presenting and immune regulatory MHC class I-related | Immunoglobulin C1-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin/major histocompatibility complex, conserved site | MHC classes I/II-like antigen recognition protein | MHC class I alpha chain, alpha1 alpha2 domains | MHC class I-like antigen recognition-like | MHC class I-like antigen recognition-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A4FUM4 | InterPro | 364 | ||||||||||
| UniProtKB:F1QEW6 | InterPro | 269 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mhc1zca-201
(1)
|
Ensembl | 810 nt | ||
| mRNA |
mhc1zca-202
(1)
|
Ensembl | 2,187 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-287J19 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:111893 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136614 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001083545 (1) | 2204 nt | ||
| Genomic | GenBank:BX005416 (1) | 163197 nt | ||
| Polypeptide | UniProtKB:A4FUM4 (1) | 364 aa |
No data available
- McConnell, S.C., Hernandez, K.M., Andrade, J., de Jong, J.L.O. (2023) Immune gene variation associated with chromosome-scale differences among individual zebrafish genomes. Scientific Reports. 13:77777777
- Honjo, Y., Takano, K., Ichinohe, T. (2020) Characterization of novel zebrafish MHC class I U lineage genes and their haplotype. Developmental and comparative immunology. 116:103952
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Dirscherl, H., Yoder, J.A. (2015) A nonclassical MHC class I U lineage locus in zebrafish with a null haplotypic variant. Immunogenetics. 67(9):501-13
- Dirscherl, H., and Yoder, J.A. (2014) Characterization of the Z lineage Major histocompatability complex class I genes in zebrafish. Immunogenetics. 66(3):185-98
- Dirscherl, H., McConnell, S.C., Yoder, J.A., de Jong, J.L. (2014) The MHC class I genes of zebrafish. Developmental and comparative immunology. 46(1):11-23
- McConnell, S.C., Restaino, A.C., and de Jong, J.L. (2014) Multiple divergent haplotypes express completely distinct sets of class I MHC genes in zebrafish. Immunogenetics. 66(3):199-213
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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