ZFIN is now using GRCz12tu for Genomic Data
Gene
rfc1
- ID
- ZDB-GENE-070410-99
- Name
- replication factor C (activator 1) 1
- Symbol
- rfc1 Nomenclature History
- Previous Names
-
- si:dkey-170e5.1
- zgc:162875 (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA binding activity and DNA clamp unloader activity. Predicted to be involved in DNA repair; DNA replication; and anatomical structure morphogenesis. Predicted to be part of DNA replication factor C complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in West Nile fever and congenital heart disease. Orthologous to human RFC1 (replication factor C subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome | 614575 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001357 | BRCT domain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR003959 | ATPase, AAA-type, core |
| Domain | IPR013725 | DNA replication factor RFC1, C-terminal |
| Domain | IPR047854 | Replication factor C, lid domain |
| Family | IPR012178 | Replication factor C subunit 1 |
| Homologous_superfamily | IPR008921 | DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036420 | BRCT domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | AAA+ ATPase domain | ATPase, AAA-type, core | BRCT domain | BRCT domain superfamily | DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal | DNA replication factor RFC1, C-terminal | P-loop containing nucleoside triphosphate hydrolase | Replication factor C, lid domain | Replication factor C subunit 1 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1Q5P6 | InterPro | 1147 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers