Gene
nrxn2b
- ID
- ZDB-GENE-070206-7
- Name
- neurexin 2b
- Symbol
- nrxn2b Nomenclature History
- Previous Names
-
- nrxn2ba
- nrxn2bb
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to be involved in sprouting angiogenesis. Predicted to act upstream of or within cell adhesion. Predicted to be located in membrane. Orthologous to human NRXN2 (neurexin 2).
- Genome Resources
- Note
-
nrxn2b has two isoforms, alpha(DQ641430) and beta(DQ641431)
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la026191Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa20840 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nrxn2b | (2) | |
| CRISPR2-nrxn2b | (2) | |
| CRISPR3-nrxn2b | (2) | |
| CRISPR4-nrxn2b | (2) | |
| CRISPR5-nrxn2b | (2) | |
| CRISPR6-nrxn2b | (2) | |
| CRISPR7-nrxn2b | (2) | |
| CRISPR8-nrxn2b | (3) | |
| CRISPR9-nrxn2b | (2) | |
| CRISPR10-nrxn2b | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001791 | Laminin G domain |
| Domain | IPR003585 | Neurexin/syndecan/glycophorin C |
| Family | IPR050372 | Neurexin-related cell adhesion and synaptic protein |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like domain | Laminin G domain | Neurexin-related cell adhesion and synaptic protein | Neurexin/syndecan/glycophorin C |
|---|---|---|---|---|---|---|---|
| UniProtKB:A1XQX6 | InterPro | 1586 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nrxn2b-201
(1)
|
Ensembl | 4,669 nt | ||
| mRNA |
nrxn2b-202
(1)
|
Ensembl | 2,715 nt | ||
| mRNA |
nrxn2b-203
(1)
|
Ensembl | 4,056 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001079984 (1) | 6700 nt | ||
| Genomic | GenBank:CABZ01078044 (1) | 34340 nt | ||
| Polypeptide | UniProtKB:A1XQX6 (1) | 1586 aa |
- Gonçalves, C., Kareklas, K., Teles, M.C., Varela, S.A.M., Costa, J., Leite, R.B., Paixão, T., Oliveira, R.F. (2022) Phenotypic architecture of sociality and its associated genetic polymorphisms in zebrafish. Genes, brain, and behavior. 21(5):e12809
- Tromp, A., Robinson, K., Hall, T.E., Mowry, B., Giacomotto, J. (2021) Pipeline for generating stable large genomic deletions in zebrafish, from small domains to whole gene excisions. G3 (Bethesda). 11(12):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Moreno-Mateos, M.A., Vejnar, C.E., Beaudoin, J.D., Fernandez, J.P., Mis, E.K., Khokha, M.K., Giraldez, A.J. (2015) CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo. Nature Methods. 12:982-8
- Shah, A.N., Davey, C.F., Whitebirch, A.C., Miller, A.C., Moens, C.B. (2015) Rapid reverse genetic screening using CRISPR in zebrafish. Nature Methods. 12(6):535-40
- Ehrmann, I., Dalgliesh, C., Liu, Y., Danilenko, M., Crosier, M., Overman, L., Arthur, H.M., Lindsay, S., Clowry, G.J., Venables, J.P., Fort, P., and Elliott, D.J. (2013) The tissue-specific RNA binding protein T-STAR controls regional splicing patterns of neurexin pre-mRNAs in the brain. PLoS Genetics. 9(4):e1003474
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Zeng, J., Yan, J., Wang, T., Mosbrook-Davis, D., Dolan, K.T., Christensen, R., Stormo, G.D., Haussler, D., Lathrop, R.H., Brachmann, R.K., and Burgess, S.M. (2008) Genome wide screens in yeast to identify potential binding sites and target genes of DNA-binding proteins. Nucleic acids research. 36(1):e8
- Rissone, A., Monopoli, M., Beltrame, M., Bussolino, F., Cotelli, F., and Arese, M. (2007) Comparative Genome Analysis of the Neurexin Gene Family in Danio rerio: Insights into Their Functions and Evolution. Mol. Biol. Evol.. 24(1):236-252
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