Gene
dctn1a
- ID
- ZDB-GENE-070117-2205
- Name
- dynactin 1a
- Symbol
- dctn1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable microtubule binding activity. Acts upstream of or within several processes, including apical protein localization; nuclear migration; and retina morphogenesis in camera-type eye. Predicted to be located in cell cortex and microtubule cytoskeleton. Predicted to be part of microtubule associated complex. Predicted to be active in axon; kinetochore; and spindle pole. Is expressed in head; muscle; nervous system; presumptive neural retina; and trunk. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and autosomal dominant distal hereditary motor neuronopathy 14. Orthologous to human DCTN1 (dynactin subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 25 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 1 | Alliance | {Amyotrophic lateral sclerosis, susceptibility to} | 105400 |
| autosomal dominant distal hereditary motor neuronopathy 14 | Alliance | Neuronopathy, distal hereditary motor, autosomal dominant 14 | 607641 |
| Perry syndrome | Alliance | Perry syndrome | 168605 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CAP Gly-rich domain | CAP Gly-rich domain superfamily | Dynein associated protein |
|---|---|---|---|---|---|
| UniProtKB:Q07DR3 | InterPro | 1218 | |||
| UniProtKB:A0A8M9Q1C7 | InterPro | 1232 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dctn1a-201
(1)
|
Ensembl | 8,004 nt | ||
| mRNA |
dctn1a-202
(1)
|
Ensembl | 3,777 nt | ||
| mRNA |
dctn1a-203
(1)
|
Ensembl | 4,304 nt | ||
| mRNA |
dctn1a-204
(1)
|
Ensembl | 4,421 nt |
Interactions and Pathways
No data available
Plasmids
No data available