Gene
dctn1a
- ID
- ZDB-GENE-070117-2205
- Name
- dynactin 1a
- Symbol
- dctn1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Involved in several processes, including apical protein localization; nuclear migration; and retina morphogenesis in camera-type eye. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and distal hereditary motor neuronopathy type 7B. Is expressed in head; nervous system; and presumptive neural retina. Orthologous to human DCTN1 (dynactin subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 25 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 1 | Alliance | {Amyotrophic lateral sclerosis, susceptibility to} | 105400 |
| distal hereditary motor neuronopathy type 7B | Alliance | Neuronopathy, distal hereditary motor, type VIIB | 607641 |
| Perry syndrome | Alliance | Perry syndrome | 168605 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | CAP Gly-rich domain | CAP Gly-rich domain superfamily | Dynein associated protein |
|---|---|---|---|---|
|
UniProtKB:A0A286YA27
|
1250 | |||
|
UniProtKB:Q07DR3
|
1218 | |||
|
UniProtKB:F1R0W9
|
1218 | |||
|
UniProtKB:Q7T2F8
|
910 | |||
|
UniProtKB:A0A2R8RP20
|
1257 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
dctn1a-201
(1)
|
8004 nt |
Interactions and Pathways
No data available
Plasmids
No data available