Gene

dctn1a

ID

ZDB-GENE-070117-2205

Name

dynactin 1a

Symbol

dctn1a Nomenclature History

Previous Names

dnct1 (1)
bug
mikre oko
mok
p150a (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Is predicted to enable microtubule plus-end binding activity. Involved in cytoplasmic microtubule organization and establishment of mitotic spindle orientation. Acts upstream of or within several processes, including apical protein localization; nuclear migration; and retina morphogenesis in camera-type eye. Predicted to be located in cytoskeleton. Predicted to be part of microtubule associated complex. Is expressed in head; muscle; nervous system; presumptive neural retina; and trunk. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and distal hereditary motor neuronopathy type 7B. Orthologous to human DCTN1 (dynactin subunit 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 25 figures from 8 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dctn1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
amyotrophic lateral sclerosis type 1	Alliance	{Amyotrophic lateral sclerosis, susceptibility to}	105400
distal hereditary motor neuronopathy type 7B	Alliance	Neuronopathy, distal hereditary motor, type VIIB	607641
Perry syndrome	Alliance	Perry syndrome	168605

Associated With dctn1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000938	CAP Gly-rich domain
Domain	IPR022157	Dynein associated protein
Homologous_superfamily	IPR036859	CAP Gly-rich domain superfamily

Domain Details Per Protein

Protein	Length	CAP Gly-rich domain	CAP Gly-rich domain superfamily	Dynein associated protein
UniProtKB:Q07DR3 InterPro	1218
UniProtKB:A0A2R8RP20 InterPro	1257
UniProtKB:A0A286YA27 InterPro	1250
UniProtKB:F1R0W9 InterPro	1218
UniProtKB:Q7T2F8 InterPro	910