them4

ID

ZDB-GENE-070112-982

Name

thioesterase superfamily member 4

Symbol

them4 Nomenclature History

Previous Names

zgc:158847

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable long-chain fatty acyl-CoA hydrolase activity. Predicted to be involved in fatty acid metabolic process and regulation of mitochondrial membrane permeability involved in apoptotic process. Predicted to act upstream of or within apoptotic process and lipid metabolic process. Predicted to be located in mitochondrial inner membrane; mitochondrial intermembrane space; and ruffle membrane. Predicted to be active in mitochondrion. Orthologous to several human genes including THEM4 (thioesterase superfamily member 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With them4 Human Ortholog

No data available

Associated With them4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006683	Thioesterase domain
Family	IPR052365	THEM4/THEM5 acyl-CoA thioesterase
Homologous_superfamily	IPR029069	HotDog domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9PMM8	InterPro	250
UniProtKB:A1L2E6	InterPro	222
UniProtKB:A0A8M9NZE6	InterPro	260
UniProtKB:F8W5N5	InterPro	236
UniProtKB:A0A8M9NZE8	InterPro	200
UniProtKB:A0A8N7UYL9	InterPro	246
UniProtKB:A0AC58HHC8	InterPro	260
UniProtKB:A0AC58HHD1	InterPro	200
UniProtKB:A0AC58HHI3	InterPro	250
UniProtKB:A0AC58HHK5	InterPro	200
UniProtKB:A0AC58HHL0	InterPro	186
UniProtKB:A0AC58HHL4	InterPro	186