Gene
ncaph
- ID
- ZDB-GENE-070112-652
- Name
- non-SMC condensin I complex, subunit H
- Symbol
- ncaph Nomenclature History
- Previous Names
-
- si:dkeyp-86b9.4
- zgc:158618
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable chromatin binding activity. Acts upstream of or within mitotic sister chromatid segregation. Predicted to be located in chromosome and cytoplasm. Predicted to be part of condensin complex. Is expressed in brain; ciliary marginal zone; optic cup; and spinal cord. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 23. Orthologous to human NCAPH (non-SMC condensin I complex subunit H).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Seipold et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Seipold et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary autosomal recessive microcephaly 23 | Alliance | ?Microcephaly 23, primary, autosomal recessive | 617985 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR022816 | Condensin complex subunit 2/barren |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Condensin complex subunit 2/barren |
|---|---|---|---|
| UniProtKB:A0A8M9PKI5 | InterPro | 690 | |
| UniProtKB:A1L231 | InterPro | 690 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-86B9 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158618 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192733 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080196 (1) | 2683 nt | ||
| Genomic | GenBank:BX323557 (2) | 223754 nt | ||
| Polypeptide | UniProtKB:A0A8M9PKI5 (1) | 690 aa |
- Qiu, W., Fang, M., Magnuson, J.T., Greer, J.B., Chen, Q., Zheng, Y., Xiong, Y., Luo, S., Zheng, C., Schlenk, D. (2020) Maternal exposure to environmental antibiotic mixture during gravid period predicts gastrointestinal effects in zebrafish offspring. Journal of hazardous materials. 399:123009
- Seipold, S., Priller, F.C., Goldsmith, P., Harris, W.A., Baier, H., and Abdelilah-Seyfried, S. (2009) Non-SMC condensin I complex proteins control chromosome segregation and survival of proliferating cells in the zebrafish neural retina. BMC Developmental Biology. 9:40
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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