Gene
slc26a1
- ID
- ZDB-GENE-070112-2182
- Name
- solute carrier family 26 member 1
- Symbol
- slc26a1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable inorganic anion transmembrane transporter activity and organic anion transmembrane transporter activity. Predicted to be involved in chloride transmembrane transport and sulfate transmembrane transport. Predicted to act upstream of or within monoatomic ion transport and transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in external yolk syncytial layer; pronephric duct; pronephric proximal convoluted tubule; and yolk syncytial layer. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis. Orthologous to human SLC26A1 (solute carrier family 26 member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb565 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa43622 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| calcium oxalate nephrolithiasis | Alliance | ?Nephrolithiasis, calcium oxalate, 1 | 167030 |
| ?Hypersulfaturia | 620372 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | SLC26A/SulP transporter | SLC26A/SulP transporter domain | STAS domain | STAS domain superfamily | Sulphate anion transporter, conserved site |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3ATV7 | InterPro | 711 | |||||
| UniProtKB:A1L1V8 | InterPro | 703 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc26a1-201
(1)
|
Ensembl | 2,687 nt | ||
| mRNA |
slc26a1-202
(1)
|
Ensembl | 2,438 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-108A2 | ZFIN Curated Data | |
| Encodes | EST | cb565 | Thisse et al., 2001 | |
| Encodes | EST | fe23c03 | ||
| Encodes | cDNA | MGC:158435 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080667 (1) | 3006 nt | ||
| Genomic | GenBank:AL844141 (1) | 257634 nt | ||
| Polypeptide | UniProtKB:A0A8M3ATV7 (1) | 711 aa |
- Schoels, M., Zhuang, M., Fahrner, A., Kuechlin, S., Sagar, S., Franz, H., Schmitt, A., Walz, G., Yakulov, T.A. (2021) Single-cell mRNA profiling reveals changes in solute carrier expression and suggests a metabolic switch during zebrafish pronephros development. American journal of physiology. Renal physiology. 320(5):F826-F837
- Sander, V., Salleh, L., Naylor, R.W., Schierding, W., Sontam, D.M., O'Sullivan, J.M., Davidson, A.J. (2019) Transcriptional profiling of the zebrafish proximal tubule. American journal of physiology. Renal physiology. 317(2):F478-F488
- Sánchez, E., Azcona, L.J., Paisán-Ruiz, C. (2018) Pla2g6 Deficiency in Zebrafish Leads to Dopaminergic Cell Death, Axonal Degeneration, Increased β-Synuclein Expression, and Defects in Brain Functions and Pathways. Molecular neurobiology. 55(8):6734-6754
- Gagnon, J.A., Obbad, K., Schier, A.F. (2017) The primary role of zebrafish nanog is in extra-embryonic tissue.. Development (Cambridge, England). 145(1)
- Tang, Q., Iyer, S., Lobbardi, R., Moore, J.C., Chen, H., Lareau, C., Hebert, C., Shaw, M.L., Neftel, C., Suva, M.L., Ceol, C.J., Bernards, A., Aryee, M., Pinello, L., Drummond, I.A., Langenau, D.M. (2017) Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing. The Journal of experimental medicine. 214(10):2875-2887
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Liu, F., Xia, W., Hu, J., Wang, Y., Yang, F., Sun, S., Zhang, J., Jiang, N., Wang, H., Tian, W., Wang, X., Ma, D. (2015) Solute Carrier Family 26 Member a2 (slc26a2) Regulates Otic Development and Hair Cell Survival in Zebrafish. PLoS One. 10:e0136832
- Xu, C., Fan, Z.P., Müller, P., Fogley, R., Dibiase, A., Trompouki, E., Unternaehrer, J., Xiong, F., Torregroza, I., Evans, T., Megason, S.G., Daley, G.Q., Schier, A.F., Young, R.A., and Zon, L.I. (2012) Nanog-like Regulates Endoderm Formation through the Mxtx2-Nodal Pathway. Developmental Cell. 22(3):625-238
- Hong, S.K., Levin, C.S., Brown, J.L., Wan, H., Sherman, B.T., Huang, D.W., Lempicki, R.A., and Feldman, B. (2010) Pre-gastrula expression of zebrafish extraembryonic genes. BMC Developmental Biology. 10:42
- Bayaa, M., Vulesevic, B., Esbaugh, A., Braun, M., Ekker, M.E., Grosell, M., and Perry, S.F. (2009) The involvement of SLC26 anion transporters in chloride uptake in zebrafish (Danio rerio) larvae. The Journal of experimental biology. 212(Pt 20):3283-3295
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