Gene
tnip1
- ID
- ZDB-GENE-070112-1502
- Name
- TNFAIP3 interacting protein 1
- Symbol
- tnip1 Nomenclature History
- Previous Names
-
- im:7141452
- zgc:158159
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to be involved in cellular response to lipopolysaccharide; negative regulation of canonical NF-kappaB signal transduction; and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Orthologous to human TNIP1 (TNFAIP3 interacting protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7141452 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-tnip1 | N/A | Serbanovic-Canic et al., 2017 |
| MO2-tnip1 | N/A | Zhou et al., 2017 |
| MO3-tnip1 | N/A | Zhou et al., 2017 |
| MO4-tnip1 | N/A | Restuadi et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR032419 | NF-kappa-B essential modulator NEMO, CC2-LZ domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | NF-kappa-B essential modulator NEMO, CC2-LZ domain |
|---|---|---|---|
| UniProtKB:A1L1N2 | InterPro | 653 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-131O13 | ZFIN Curated Data | |
| Contained in | BAC | CH211-174H24 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7141452 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:158159 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001079952 (1) | 2429 nt | ||
| Genomic | GenBank:CT997810 (1) | 136529 nt | ||
| Polypeptide | UniProtKB:A1L1N2 (1) | 653 aa |
- Restuadi, R., Steyn, F.J., Kabashi, E., Ngo, S.T., Cheng, F.F., Nabais, M.F., Thompson, M.J., Qi, T., Wu, Y., Henders, A.K., Wallace, L., Bye, C.R., Turner, B.J., Ziser, L., Mathers, S., McCombe, P.A., Needham, M., Schultz, D., Kiernan, M.C., van Rheenen, W., van den Berg, L.H., Veldink, J.H., Ophoff, R., Gusev, A., Zaitlen, N., McRae, A.F., Henderson, R.D., Wray, N.R., Giacomotto, J., Garton, F.C. (2022) Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1. Genome Medicine. 14:7
- Li, X., Alhasani, R.H., Cao, Y., Zhou, X., He, Z., Zeng, Z., Strang, N., Shu, X. (2021) Gypenosides Alleviate Cone Cell Death in a Zebrafish Model of Retinitis Pigmentosa. Antioxidants (Basel, Switzerland). 10(7):
- Serbanovic-Canic, J., de Luca, A., Warboys, C., Ferreira, P.F., Luong, L.A., Hsiao, S., Gauci, I., Mahmoud, M., Feng, S., Souilhol, C., Bowden, N., Ashton, J.P., Walczak, H., Firmin, D., Krams, R., Mason, J.C., Haskard, D.O., Sherwin, S., Ridger, V., Chico, T.J., Evans, P.C. (2017) Zebrafish Model for Functional Screening of Flow-Responsive Genes. Arteriosclerosis, Thrombosis, and Vascular Biology. 37(1):130-143
- Zhou, P., Jiang, J., Yan, H., Li, Y., Zhao, J., Wang, X., Su, R., Gong, Z. (2017) ABIN-1 Negatively Regulates μ-Opioid Receptor Function.. Molecular pharmacology. 93(2):36-48
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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