Gene
slc6a7
- ID
- ZDB-GENE-070112-1492
- Name
- solute carrier family 6 member 7
- Symbol
- slc6a7 Nomenclature History
- Previous Names
-
- zgc:158225 (1)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable amino acid:sodium symporter activity. Acts upstream of or within neuron projection morphogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Reid et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Sodium:neurotransmitter symporter | Sodium:neurotransmitter symporter superfamily |
|---|---|---|---|---|
| UniProtKB:A1L1P6 | InterPro | 537 | ||
| UniProtKB:F1R3N3 | InterPro | 652 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc6a7-201
(1)
|
Ensembl | 4,329 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-22F5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158225 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080580 (1) | 4086 nt | ||
| Genomic | GenBank:BX511168 (1) | 245435 nt | ||
| Polypeptide | UniProtKB:F1R3N3 (1) | 652 aa |
- Comparative Orthology
- Alliance
No data available
- Reid, K.M., Spaull, R., Salian, S., Barwick, K., Meyer, E., Zhen, J., Hirata, H., Sheipouri, D., Benkerroum, H., Gorman, K.M., Papandreou, A., Simpson, M.A., Hirano, Y., Farabella, I., Topf, M., Grozeva, D., Carss, K., Smith, M., Pall, H., Lunt, P., De Gressi, S., Kamsteeg, E.J., Haack, T.B., Carr, L., Guerreiro, R., Bras, J., Maher, E.R., Scott, R.H., Vandenberg, R.J., Raymond, F.L., Chong, W.K., Sudhakar, S., Mankad, K., Reith, M.E., Campeau, P.M., Harvey, R.J., Kurian, M.A. (2022) MED27, SLC6A7, and MPPE1 Variants in a Complex Neurodevelopmental Disorder with Severe Dystonia. Movement disorders : official journal of the Movement Disorder Society. 37(10):2139-2146
- Tang, W., Davidson, J.D., Zhang, G., Conen, K.E., Fang, J., Serluca, F., Li, J., Xiong, X., Coble, M., Tsai, T., Molind, G., Fawcett, C.H., Sanchez, E., Zhu, P., Couzin, I.D., Fishman, M.C. (2020) Genetic Control of Collective Behavior in Zebrafish. iScience. 23:100942
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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