Gene
cyp21a2
- ID
- ZDB-GENE-070103-6
- Name
- cytochrome P450, family 21, subfamily A, polypeptide 2
- Symbol
- cyp21a2 Nomenclature History
- Previous Names
-
- cyp21a1 (1)
- si:ch1073-443n13.1
- si:ch211-257p13.4
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have heme binding activity; iron ion binding activity; and oxidoreductase activity. Involved in glucocorticoid biosynthetic process. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Is expressed in brain; head; and renal system. Orthologous to human CYP21A2 (cytochrome P450 family 21 subfamily A member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Eachus et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital adrenal hyperplasia | Alliance | Adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency | 201910 |
| congenital adrenal hyperplasia | Alliance | Hyperandrogenism, nonclassic type, due to 21-hydroxylase deficiency | 201910 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450 superfamily |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M9NZM6
|
522 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
cyp21a2-201
(1)
|
Havana | 1828 nt |
Interactions and Pathways
No data available
Plasmids
No data available