ZFIN is now using GRCz12tu for Genomic Data

Gene

epoa

ID

ZDB-GENE-061218-3

Name

erythropoietin a

Symbol

epoa Nomenclature History

Previous Names

epo

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable cytokine activity. Acts upstream of or within nucleate erythrocyte development; pronephros development; and response to activity. Located in perinuclear region of cytoplasm. Is expressed in several structures, including brain; digestive system; eye; heart; and immune system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic angiopathy; familial erythrocytosis 5; ischemia (multiple); and neurodegenerative disease (multiple). Orthologous to human EPO (erythropoietin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

29 figures from 20 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 16 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With epoa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
familial erythrocytosis 5	Alliance	Erythrocytosis, familial, 5	617907
		?Diamond-Blackfan anemia-like	617911
		{Microvascular complications of diabetes 2}	612623

Associated With epoa Via Experimental Models

Human Disease	Fish	Conditions	Citations
Diamond-Blackfan anemia	epoa^szy8/szy8	standard conditions	Ling et al., 2024

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR001323	Erythropoietin/thrombopoietin
Family	IPR003013	Erythropoietin
Homologous_superfamily	IPR009079	Four-helical cytokine-like, core

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:B1N8Y2	InterPro	171
UniProtKB:B1N8Y1	InterPro	186
UniProtKB:B3DI26	InterPro	183
UniProtKB:Q2XNF5	InterPro	183

Transcripts

Genome Browsers

NCBI Map Viewer

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	epoa-201 (1) Ensembl	Ensembl	1,825 nt	Select Tool ZFIN BLAST
mRNA	epoa-202 (1) Ensembl	Ensembl	1,262 nt	Select Tool ZFIN BLAST
mRNA	epoa-203 (1) Ensembl	Ensembl	1,312 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Addgene:pHis-zfEpoa

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations