ZFIN is now using GRCz12tu for Genomic Data
Gene
kcnq1.1
- ID
- ZDB-GENE-061214-5
- Name
- potassium voltage-gated channel, KQT-like subfamily, member 1.1
- Symbol
- kcnq1.1 Nomenclature History
- Previous Names
-
- kcnq1
- zgc:158384
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable outward rectifier potassium channel activity; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization; and voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. Predicted to be involved in membrane repolarization during ventricular cardiac muscle cell action potential and potassium ion export across plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in brain; heart; and inner ear. Human ortholog(s) of this gene implicated in heart conduction disease (multiple); long QT syndrome (multiple); and type 2 diabetes mellitus. Orthologous to human KCNQ1 (potassium voltage-gated channel subfamily Q member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Liu et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial atrial fibrillation | Alliance | Atrial fibrillation, familial, 3 | 607554 |
| Jervell-Lange Nielsen syndrome | Alliance | Jervell and Lange-Nielsen syndrome | 220400 |
| long QT syndrome 1 | Alliance | Long QT syndrome 1 | 192500 |
| long QT syndrome 1 | Alliance | {Long QT syndrome 1, acquired, susceptibility to} | 192500 |
| short QT syndrome | Alliance | Short QT syndrome 2 | 609621 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR013821 | Potassium channel, voltage dependent, KCNQ, C-terminal |
| Family | IPR003937 | Potassium channel, voltage dependent, KCNQ |
| Family | IPR005827 | Potassium channel, voltage dependent, KCNQ1 |
| Homologous_superfamily | IPR027359 | Voltage-dependent channel domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Ion transport domain | Potassium channel, voltage dependent, KCNQ | Potassium channel, voltage dependent, KCNQ1 | Potassium channel, voltage dependent, KCNQ, C-terminal | Voltage-dependent channel domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A286YA22 | InterPro | 643 | |||||
| UniProtKB:B0R0K2 | InterPro | 655 | |||||
| UniProtKB:A0AC58FZ01 | InterPro | 669 | |||||
| UniProtKB:A0AC58FZ06 | InterPro | 657 | |||||
| UniProtKB:A0AC58FZ33 | InterPro | 511 | |||||
| UniProtKB:A0AC58FZC7 | InterPro | 523 | |||||
| UniProtKB:A0AC58FZG3 | InterPro | 511 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers