Gene
evi5l
- ID
- ZDB-GENE-061207-24
- Name
- ecotropic viral integration site 5 like
- Symbol
- evi5l Nomenclature History
- Previous Names
-
- si:ch211-239f4.1
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity and small GTPase binding activity. Is expressed in telencephalon. Orthologous to human EVI5L (ecotropic viral integration site 5 like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Diotel et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028159Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028160Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa12742 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15533 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17572 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17798 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19554 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32739 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zko876a | Allele with one delins | Unknown | Unknown | CRISPR | |
| zko876b | Allele with one delins | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000195 | Rab-GAP-TBC domain |
| Domain | IPR013087 | Zinc finger C2H2-type |
| Family | IPR050302 | Rab GTPase-activating TBC domain-containing protein |
| Homologous_superfamily | IPR035969 | Rab-GAP-TBC domain superfamily |
| Homologous_superfamily | IPR036236 | Zinc finger C2H2 superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Rab-GAP-TBC domain | Rab-GAP-TBC domain superfamily | Rab GTPase-activating TBC domain-containing protein | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3ARW8 | InterPro | 985 | |||||
| UniProtKB:A0A8M3AUU5 | InterPro | 996 | |||||
| UniProtKB:A0A8M9Q053 | InterPro | 964 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-239F4 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009293538 (1) | |||
| Genomic | GenBank:AL953855 (1) | 146080 nt | ||
| Polypeptide | UniProtKB:A0A8M3AUU5 (1) | 996 aa |
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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