Gene
mical2b
- ID
- ZDB-GENE-061207-15
- Name
- microtubule associated monooxygenase, calponin and LIM domain containing 2b
- Symbol
- mical2b Nomenclature History
- Previous Names
-
- sb:cb94
- si:ch211-192p3.1
- si:ch211-192p3.2
- wu:fi76d02
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable actin binding activity and oxidoreductase activity. Involved in heart looping. Predicted to be located in nucleus. Is expressed in several structures, including cardiovascular system; digestive system; fin; mesoderm; and sensory system. Orthologous to human MICAL2 (microtubule associated monooxygenase, calponin and LIM domain containing 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb94 (21 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la023160Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la023161Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028674Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa24630 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa31109 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-mical2b | N/A | Manchenkov et al., 2015 |
| TALEN1-mical2b | Xiao et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | bMERB domain | Calponin homology domain | CH domain superfamily | F-actin Monooxygenase Mical | FAD-binding domain | FAD/NAD(P)-binding domain superfamily | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PV03 | InterPro | 1656 | |||||||
| UniProtKB:F1RA39 | InterPro | 1679 | |||||||
| UniProtKB:A0A8M9P6G8 | InterPro | 1567 | |||||||
| UniProtKB:A0A8M9PYF5 | InterPro | 1668 | |||||||
| UniProtKB:A0A8M9PYG2 | InterPro | 1120 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mical2b-201
(1)
|
Ensembl | 3,363 nt | ||
| mRNA |
mical2b-202
(1)
|
Ensembl | 5,425 nt | ||
| mRNA |
mical2b-203
(1)
|
Ensembl | 4,899 nt | ||
| mRNA |
mical2b-204
(1)
|
Ensembl | 5,797 nt | ||
| mRNA |
mical2b-205
(1)
|
Ensembl | 5,728 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-166I5 | ZFIN Curated Data | |
| Contained in | BAC | CH211-192P3 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-80C24 | ZFIN Curated Data | |
| Encodes | EST | cb94 | Thisse et al., 2001 | |
| Encodes | EST | fi76d02 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001271913 (1) | 5050 nt | ||
| Genomic | GenBank:CR759887 (1) | 215263 nt | ||
| Polypeptide | UniProtKB:A0A8M9PMS9 (1) | 1679 aa |
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Manchenkov, T., Pasillas, M.P., Haddad, G.G., Imam, F.B. (2015) Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism. G3 (Bethesda). 5(6):1107-16
- Lundquist, M.R., Storaska, A.J., Liu, T.C., Larsen, S.D., Evans, T., Neubig, R.R., Jaffrey, S.R. (2014) Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.. Cell. 156(3):563-76
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Xiao, A., Wang, Z., Hu, Y., Wu, Y., Luo, Z., Yang, Z., Zu, Y., Li, W., Huang, P., Tong, X., Zhu, Z., Lin, S., and Zhang, B. (2013) Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish. Nucleic acids research. 41(14):e141
- Xue, Y., Kuok, C., Xiao, A., Zhu, Z., Lin, S., and Zhang, B. (2010) Identification and expression analysis of mical family genes in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 37(10):685-693
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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