ZFIN is now using GRCz12tu for Genomic Data
Gene
aoc1
- ID
- ZDB-GENE-061103-112
- Name
- amine oxidase copper containing 1
- Symbol
- aoc1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable copper ion binding activity; diamine oxidase activity; and primary methylamine oxidase activity. Predicted to be involved in putrescine metabolic process. Predicted to be active in plasma membrane. Is expressed in ventral habenular nucleus. Orthologous to human AOC1 (amine oxidase copper containing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR049947 | Copper amine oxidase, copper-binding site |
| Conserved_site | IPR049948 | Copper amine oxidase, TPQ-binding site |
| Domain | IPR015798 | Copper amine oxidase, catalytic domain |
| Domain | IPR015800 | Copper amine oxidase, N2-terminal |
| Domain | IPR015802 | Copper amine oxidase, N3-terminal |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Copper amine oxidase | Copper amine oxidase, catalytic domain | Copper amine oxidase, catalytic domain superfamily | Copper amine oxidase, copper-binding site | Copper amine oxidase, N2-terminal | Copper amine oxidase, N3-terminal | Copper amine oxidase, N-terminal | Copper amine oxidase, TPQ-binding site |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0JMP5 | InterPro | 742 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(aoc1:Cre-mCherry) |
|
| 1 | (3) | |
| TgBAC(aoc1:GAL4-VP16) |
|
| 1 | (5) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-286C5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:154101 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077598 (1) | 2635 nt | ||
| Genomic | GenBank:BX323854 (1) | 161864 nt | ||
| Polypeptide | UniProtKB:A0JMP5 (1) | 742 aa |
- Powell, G.T., Faro, A., Zhao, Y., Stickney, H., Novellasdemunt, L., Henriques, P., Gestri, G., Redhouse White, E., Ren, J., Lu, W., Young, R.M., Hawkins, T.A., Cavodeassi, F., Schwarz, Q., Dreosti, E., Raible, D.W., Li, V.S.W., Wright, G.J., Jones, E.Y., Wilson, S.W. (2024) Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.). 384:573579573-579
- Zhang, M.Q., Chen, B., Zhang, J.P., Chen, N., Liu, C.Z., Hu, C.Q. (2020) Liver toxicity of macrolide antibiotics in zebrafish. Toxicology. 441:152501
- Choi, J.H., Jeong, Y.M., Kim, S., Lee, B., Ariyasiri, K., Kim, H.T., Jung, S.H., Hwang, K.S., Choi, T.I., Park, C.O., Huh, W.K., Carl, M., Rosenfeld, J.A., Raskin, S., Ma, A., Gecz, J., Kim, H.G., Kim, J.S., Shin, H.C., Park, D.S., Gerlai, R., Jamieson, B.B., Kim, J.S., Iremonger, K.J., Lee, S.H., Shin, H.S., Kim, C.H. (2018) Targeted knockout of a chemokine-like gene increases anxiety and fear responses. Proceedings of the National Academy of Sciences of the United States of America. 115(5):E1041-E1050
- Pandey, S., Shekhar, K., Regev, A., Schier, A.F. (2018) Comprehensive Identification and Spatial Mapping of Habenular Neuronal Types Using Single-Cell RNA-Seq. Current biology : CB. 28(7):1052-1065.e7
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kuan, Y.S., Roberson, S., Akitake, C.M., Fortuno, L., Gamse, J., Moens, C., Halpern, M.E. (2015) Distinct requirements for Wntless in habenular development. Developmental Biology. 406(2):117-28
- Amo, R., Fredes, F., Kinoshita, M., Aoki, R., Aizawa, H., Agetsuma, M., Aoki, T., Shiraki, T., Kakinuma, H., Matsuda, M., Yamazaki, M., Takahoko, M., Tsuboi, T., Higashijima, S.I., Miyasaka, N., Koide, T., Yabuki, Y., Yoshihara, Y., Fukai, T., Okamoto, H. (2014) The Habenulo-Raphe Serotonergic Circuit Encodes an Aversive Expectation Value Essential for Adaptive Active Avoidance of Danger. Neuron. 84:1034-1048
- Dean, B.J., Erdogan, B., Gamse, J.T., Wu, S.Y. (2014) Dbx1b defines the dorsal habenular progenitor domain in the zebrafish epithalamus. Neural Development. 9:20
- deCarvalho, T.N., Subedi, A., Rock, J., Harfe, B.D., Thisse, C., Thisse, B., Halpern, M.E., Hong, E. (2014) Neurotransmitter map of the asymmetric dorsal habenular nuclei of zebrafish. Genesis (New York, N.Y. : 2000). 52(6):636-55
- Hong, E., Santhakumar, K., Akitake, C.A., Ahn, S.J., Thisse, C., Thisse, B., Wyart, C., Mangin, J.M., and Halpern, M.E. (2013) Cholinergic left-right asymmetry in the habenulo-interpeduncular pathway. Proceedings of the National Academy of Sciences of the United States of America. 110(52):21171-21176
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