Gene
proza
- ID
- ZDB-GENE-061013-403
- Name
- protein Z, vitamin K-dependent plasma glycoprotein a
- Symbol
- proza Nomenclature History
- Previous Names
-
- wu:fj51g06
- zgc:152997 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Is predicted to enable calcium ion binding activity and serine-type endopeptidase activity. Acts upstream of or within blood coagulation and proteolysis. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in Behcet's disease and brain ischemia. Orthologous to human PROZ (protein Z, vitamin K dependent plasma glycoprotein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| [Protein Z deficiency] | 614024 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000294 | Gamma-carboxyglutamic acid-rich (GLA) domain |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001254 | Serine proteases, trypsin domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Family | IPR012224 | Peptidase S1A, coagulation factor VII/IX/X/C/Z |
| Homologous_superfamily | IPR009003 | Peptidase S1, PA clan |
| Homologous_superfamily | IPR017857 | Coagulation factor-like, Gla domain superfamily |
| Homologous_superfamily | IPR035972 | Gamma-carboxyglutamic acid-rich (GLA) domain superfamily |
| Homologous_superfamily | IPR043504 | Peptidase S1, PA clan, chymotrypsin-like fold |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Length | Coagulation factor-like, Gla domain superfamily | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Gamma-carboxyglutamic acid-rich (GLA) domain | Gamma-carboxyglutamic acid-rich (GLA) domain superfamily | Peptidase S1A, coagulation factor VII/IX/X/C/Z | Peptidase S1, PA clan | Peptidase S1, PA clan, chymotrypsin-like fold | Serine proteases, trypsin domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q08BQ2
|
196 | |||||||||||
|
UniProtKB:A0A286Y878
|
198 | |||||||||||
|
UniProtKB:F1Q6I8
|
196 | |||||||||||
|
UniProtKB:F1Q5S2
|
426 |
Interactions and Pathways
No data available
Plasmids
No data available