Gene
nedd9
- ID
- ZDB-GENE-061013-318
- Name
- neural precursor cell expressed, developmentally down-regulated 9
- Symbol
- nedd9 Nomenclature History
- Previous Names
-
- fc45g12
- wu:fc45g12
- zgc:154043
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to be involved in cell migration and cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be located in axon and focal adhesion. Predicted to be active in cytoplasm. Predicted to colocalize with plasma membrane. Is expressed in retina. Orthologous to human NEDD9 (neural precursor cell expressed, developmentally down-regulated 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Owen et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa23415 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CAS family | CAS family, C-terminal | CAS, serine rich four helix bundle domain superfamily | Enhancer of filamentation 1, SH3 domain | Serine rich protein interaction domain | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q08BB0 | InterPro | 783 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-364O13 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-206D17 | ZFIN Curated Data | |
| Contained in | BAC | RP71-18L21 | ZFIN Curated Data | |
| Encodes | EST | fc45g12 | ||
| Encodes | cDNA | MGC:154043 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191747 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077282 (1) | 2938 nt | ||
| Genomic | GenBank:CT030005 | 179122 nt | ||
| Polypeptide | UniProtKB:Q08BB0 (1) | 783 aa |
- Owen, N., Toms, M., Young, R.M., Eintracht, J., Sarkar, H., Brooks, B.P., Moosajee, M., Genomics England Research Consortium (2022) Identification of 4 novel human ocular coloboma genes ANK3, BMPR1B, PDGFRA, and CDH4 through evolutionary conserved vertebrate gene analysis. Genetics in medicine : official journal of the American College of Medical Genetics. 24(5):1073-1084
- Braasch, I., Volff, J.N., and Schartl, M. (2009) The endothelin system: evolution of vertebrate-specific ligand-receptor interactions by three rounds of genome duplication. Mol. Biol. Evol.. 26(4):783-799
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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