Gene
igfals
- ID
- ZDB-GENE-061009-25
- Name
- insulin-like growth factor binding protein, acid labile subunit
- Symbol
- igfals Nomenclature History
- Previous Names
-
- si:ch211-66h3.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable insulin-like growth factor binding activity and signaling receptor activity. Acts upstream of or within dorsal/ventral pattern formation. Predicted to be located in extracellular region. Predicted to be part of insulin-like growth factor ternary complex. Is expressed in brain; digestive system; heart; muscle; and pleuroperitoneal region. Orthologous to human IGFALS (insulin like growth factor binding protein acid labile subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Landi et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa20119 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 1 of 1
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Acid-labile subunit, deficiency of | 615961 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000372 | Leucine-rich repeat N-terminal domain |
| Family | IPR050328 | Multifunctional Developmental and Immune Receptor |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
1 - 5 of 5
Domain Details Per Protein
| Protein | Additional Resources | Length | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat N-terminal domain | Leucine-rich repeat, typical subtype | Multifunctional Developmental and Immune Receptor |
|---|---|---|---|---|---|---|---|
| UniProtKB:E9QJJ1 | InterPro | 614 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
igfals-201
(1)
|
Ensembl | 1,845 nt | ||
| mRNA |
igfals-202
(1)
|
Ensembl | 3,081 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-66H3 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_003198155 (1) | 3081 nt | ||
| Genomic | GenBank:BX323991 (1) | 174390 nt | ||
| Polypeptide | UniProtKB:E9QJJ1 (1) | 614 aa |
- Landi, E., Karabatas, L., Gómez, T.R., Salatino, L., Scaglia, P., Ramírez, L., Keselman, A., Braslavsky, D., Sanguineti, N., Pennisi, P., Rey, R.A., Bergadá, I., Jasper, H.G., Domené, H.M., Plazas, P.V., Domené, S. (2023) An in vivo functional assay to characterize human STAT5B genetic variants during zebrafish development. Human molecular genetics. 32(15):2473-2484
- Knuth, M.M., Mahapatra, D., Jima, D., Wan, D., Hammock, B.D., Law, M., Kullman, S.W. (2020) Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish. Scientific Reports. 10:16032
- Landi, E., Karabatas, L., Scaglia, P., Pisciottano, F., Gutierrez, M., Ramirez, L., Bergadá, I., Rey, R., Guillermo Jasper, H., Mario Domené, H., Viviana Plazas, P., Domené, S. (2020) Expression of acid-labile subunit (als) in developing and adult zebrafish and its role in dorso-ventral patterning during development. General and comparative endocrinology. 299:113591
- Fei, F., Sun, S.Y., Yao, Y.X., Wang, X. (2017) [Generation and phenotype analysis of zebrafish mutations of obesity-related genes lepr and mc4r]. Sheng li xue bao : [Acta physiologica Sinica]. 69:61-69
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
1 - 5 of 5
Show