ZFIN is now using GRCz12tu for Genomic Data
Gene
june
- ID
- ZDB-GENE-060929-812
- Name
- JunE proto-oncogene, AP-1 transcription factor subunit
- Symbol
- june Nomenclature History
- Previous Names
-
- zgc:153924
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including positive regulation of transcription by RNA polymerase II; regulation of cell cycle; and response to steroid hormone. Predicted to be part of transcription regulator complex.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Dogra et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-june | (2) | |
| CRISPR2-june | (2) | |
| CRISPR3-june | (2) | |
| CRISPR4-june | (2) | |
| CRISPR5-june | (2) | |
| CRISPR6-june | (2) | |
| CRISPR7-june | (2) | |
| CRISPR8-june | (2) | |
| CRISPR9-june | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004827 | Basic-leucine zipper domain |
| Domain | IPR005643 | Jun-like transcription factor |
| Family | IPR002112 | Transcription factor Jun |
| Family | IPR050946 | AP-1 Transcription Factor bZIP |
| Homologous_superfamily | IPR008917 | Transcription factor, Skn-1-like, DNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | AP-1 Transcription Factor bZIP | Basic-leucine zipper domain | Basic-leucine zipper domain superfamily | Jun-like transcription factor | Transcription factor Jun | Transcription factor, Skn-1-like, DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q08BZ3 | InterPro | 323 | ||||||
| UniProtKB:A0AB13ABU6 | InterPro | 327 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | cDNA | MGC:153924 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174977 | ZFIN Curated Data |
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- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001431134 (1) | 3167 nt | ||
| Genomic | GenBank:JBMGRA010000005 (1) | |||
| Polypeptide | UniProtKB:A0AB13ABU6 (1) | 327 aa |
No data available
- Xin, G., Li, W.G., Yoganandham, S.T., Jia, P.P., Ma, Y.B., Pei, D.S. (2020) Gut bacteria Vibrio sp. and Aeromonas sp. trigger the expression levels of proinflammatory cytokine: First evidence from the germ-free zebrafish. Fish & shellfish immunology. 106:518-525
- Dogra, D., Ahuja, S., Kim, H.T., Rasouli, S.J., Stainier, D.Y.R., Reischauer, S. (2017) Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair. Nature communications. 8:1902
- Moreno-Mateos, M.A., Vejnar, C.E., Beaudoin, J.D., Fernandez, J.P., Mis, E.K., Khokha, M.K., Giraldez, A.J. (2015) CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo. Nature Methods. 12:982-8
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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