ZFIN is now using GRCz12tu for Genomic Data
Gene
prkar1b
- ID
- ZDB-GENE-060929-580
- Name
- protein kinase, cAMP-dependent, regulatory, type I, beta
- Symbol
- prkar1b Nomenclature History
- Previous Names
-
- zgc:153624
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cAMP binding activity; cAMP-dependent protein kinase inhibitor activity; and protein kinase A catalytic subunit binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of cAMP-dependent protein kinase complex. Predicted to be active in cytosol. Is expressed in male organism. Human ortholog(s) of this gene implicated in disease of mental health. Orthologous to human PRKAR1B (protein kinase cAMP-dependent type I regulatory subunit beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Ma et al., 2025
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Marbach-Schaaf neurodevelopmental syndrome | 619680 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018488 | Cyclic nucleotide-binding, conserved site |
| Domain | IPR000595 | Cyclic nucleotide-binding domain |
| Domain | IPR003117 | cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain |
| Domain | IPR042818 | RIbeta, dimerization/docking domain |
| Family | IPR012198 | cAMP-dependent protein kinase regulatory subunit |
| Family | IPR050503 | cAMP-dependent protein kinase regulatory subunit-like |
| Homologous_superfamily | IPR014710 | RmlC-like jelly roll fold |
| Homologous_superfamily | IPR018490 | Cyclic nucleotide-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | cAMP-dependent protein kinase regulatory subunit | cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain | cAMP-dependent protein kinase regulatory subunit-like | Cyclic nucleotide-binding, conserved site | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | RIbeta, dimerization/docking domain | RmlC-like jelly roll fold |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q08C49 | InterPro | 380 | ||||||||
| UniProtKB:A0AC58IZM8 | InterPro | 380 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prkar1b-201
(1)
|
Ensembl | 1,366 nt | ||
| mRNA |
prkar1b-202
(1)
|
Ensembl | 1,428 nt | ||
| mRNA |
prkar1b-203
(1)
|
Ensembl | 1,182 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers