Gene
aplnra
- ID
- ZDB-GENE-060929-512
- Name
- apelin receptor a
- Symbol
- aplnra Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables apelin receptor activity. Involved in heart development. Acts upstream of with a positive effect on Kupffer's vesicle development. Acts upstream of or within with a positive effect on determination of heart left/right asymmetry and determination of liver left/right asymmetry. Acts upstream of or within gastrulation; regulation of nodal signaling pathway; and vasculature development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including blastoderm; blastomere; cardiovascular system; immature eye; and mesoderm. Orthologous to human APLNR (apelin receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| imb1 | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | TALEN | |
| mu296 | Allele with one delins | Exon 1 | Premature Stop | TALEN | |
| zm00177433Tg | Transgenic insertion | Exon 1 | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-aplnra | (2) | |
| CRISPR2-aplnra | Zhu et al., 2019 | |
| CRISPR3-aplnra | Zhu et al., 2019 | |
| CRISPR4-aplnra | Zhu et al., 2019 | |
| CRISPR5-aplnra | Zhu et al., 2019 | |
| MO1-aplnra | N/A | (4) |
| MO2-aplnra | N/A | (2) |
| MO3-aplnra | N/A | Nornes et al., 2009 |
| MO4-aplnra | N/A | Nornes et al., 2009 |
| MO5-aplnra | N/A | Nornes et al., 2009 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Angiotensin II receptor family | C-C chemokine receptor type 1-9-like | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|---|
| UniProtKB:B2GPM9 | InterPro | 362 | ||||
| UniProtKB:Q7SZP9 | InterPro | 362 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
aplnra-201
(1)
|
Ensembl | 1,708 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-87L2 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-259P11 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:66060 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:152843 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191579 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001075105 (1) | 1487 nt | ||
| Genomic | GenBank:BX248505 | 189425 nt | ||
| Polypeptide | UniProtKB:B2GPM9 (1) | 362 aa |
- Wang, Z.Y., Mehra, A., Wang, Q.C., Gupta, S., Ribeiro da Silva, A., Juan, T., Günther, S., Looso, M., Detleffsen, J., Stainier, D.Y.R., Marín-Juez, R. (2024) flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response. Development (Cambridge, England). 151(23):
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- Paulissen, E., Palmisano, N.J., Waxman, J., Martin, B.L. (2022) Somite morphogenesis is required for axial blood vessel formation during zebrafish embryogenesis. eLIFE. 11:
- Qi, J., Rittershaus, A., Priya, R., Mansingh, S., Stainier, D.Y.R., Helker, C.S.M. (2022) Apelin signaling dependent endocardial protrusions promote cardiac trabeculation in zebrafish. eLIFE. 11:
- Stock, J., Kazmar, T., Schlumm, F., Hannezo, E., Pauli, A. (2022) A self-generated Toddler gradient guides mesodermal cell migration. Science advances. 8:eadd2488
- Zhang, X., Yang, Y., Wei, Y., Zhao, Q., Lou, X. (2022) Blf and drl cluster synergistically regulate cell fate commitment during zebrafish primitive hematopoiesis. Development (Cambridge, England). 149(24)
- Ding, Y., Wang, W., Ma, D., Liang, G., Kang, Z., Xue, Y., Zhang, Y., Wang, L., Heng, J., Zhang, Y., Liu, F. (2020) Smarca5 mediated epigenetic programming facilitates fetal HSPC development in vertebrates. Blood. 137(2):190-202
- Helker, C.S., Eberlein, J., Wilhelm, K., Sugino, T., Malchow, J., Schuermann, A., Baumeister, S., Kwon, H.B., Maischein, H.M., Potente, M., Herzog, W., Stainier, D.Y. (2020) Apelin signaling drives vascular endothelial cells towards a pro-angiogenic state. eLIFE. 9:e55589
- Lange, C., Rost, F., Machate, A., Reinhardt, S., Lesche, M., Weber, A., Kuscha, V., Dahl, A., Rulands, S., Brand, M. (2020) Single cell sequencing of radial glia progeny reveals diversity of newborn neurons in the adult zebrafish brain. Development (Cambridge, England). 147(1):
- Wang, Y., Zhang, D., Zhou, F., Zhou, M., Li, Q., Chen, J., Yang, J. (2020) Whole-Mount In Situ Hybridization in Zebrafish Embryos and Tube Formation Assay in iPSC-ECs to Study the Role of Endoglin in Vascular Development. Journal of visualized experiments : JoVE. (159):
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