Gene
rnf220a
- ID
- ZDB-GENE-060929-1006
- Name
- ring finger protein 220a
- Symbol
- rnf220a Nomenclature History
- Previous Names
-
- zgc:153254
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin protein ligase activity. Involved in spinal cord patterning. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 23. Orthologous to human RNF220 (ring finger protein 220).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ma et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypomyelinating leukodystrophy 23 | Alliance | Leukodystrophy, hypomyelinating, 23, with ataxia, deafness, liver dysfunction, and dilated cardiomyopathy | 619688 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR031824 | E3 ubiquitin-protein ligase RNF220, middle domain |
| Domain | IPR040178 | E3 ubiquitin-protein ligase RNF220, RING finger |
| Family | IPR052443 | E3 ubiquitin-protein ligase RNF220-like |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
Domain Details Per Protein
| Protein | Additional Resources | Length | E3 ubiquitin-protein ligase RNF220-like | E3 ubiquitin-protein ligase RNF220, middle domain | E3 ubiquitin-protein ligase RNF220, RING finger | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QNG6 | InterPro | 669 | |||||
| UniProtKB:A0A8M9PY31 | InterPro | 333 | |||||
| UniProtKB:A0A8M9Q9U5 | InterPro | 634 | |||||
| UniProtKB:A0A8M9PY03 | InterPro | 638 | |||||
| UniProtKB:A0A8M9QJR7 | InterPro | 660 | |||||
| UniProtKB:A0A8M9QJS5 | InterPro | 399 | |||||
| UniProtKB:A0A8M9QFI1 | InterPro | 577 | |||||
| UniProtKB:A0A8M9QFJ4 | InterPro | 307 | |||||
| UniProtKB:A0A8M9Q9V4 | InterPro | 364 | |||||
| UniProtKB:Q08CD0 | InterPro | 307 | |||||
| UniProtKB:A0A8M9PXZ7 | InterPro | 695 | |||||
| UniProtKB:A0A8M9QFH8 | InterPro | 615 | |||||
| UniProtKB:A0A8M9PY10 | InterPro | 603 | |||||
| UniProtKB:A0A8M9Q9V8 | InterPro | 338 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
rnf220a-205
(1)
|
Ensembl | 855 nt | ||
| mRNA |
rnf220a-201
(1)
|
Ensembl | 1,614 nt | ||
| mRNA |
rnf220a-202
(1)
|
Ensembl | 1,734 nt | ||
| mRNA |
rnf220a-203
(1)
|
Ensembl | 762 nt | ||
| mRNA |
rnf220a-204
(1)
|
Ensembl | 694 nt | ||
| mRNA |
rnf220a-206
(1)
|
Ensembl | 604 nt | ||
| mRNA |
rnf220a-207
(1)
|
Ensembl | 1,339 nt | ||
| mRNA |
rnf220a-208
(1)
|
Ensembl | 2,707 nt | ||
| mRNA |
rnf220a-209
(1)
|
Ensembl | 5,466 nt |
Interactions and Pathways
No data available
Plasmids
No data available