Gene

ears2

ID
ZDB-GENE-060825-214
Name
glutamyl-tRNA synthetase 2, mitochondrial
Symbol
ears2 Nomenclature History
Previous Names
  • zgc:153247
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to enable glutamate-tRNA ligase activity. Predicted to be involved in glutamyl-tRNA aminoacylation. Predicted to act upstream of or within tRNA aminoacylation for protein translation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 12. Orthologous to human EARS2 (glutamyl-tRNA synthetase 2, mitochondrial).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ears2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
combined oxidative phosphorylation deficiency 12 Alliance Combined oxidative phosphorylation deficiency 12 614924
Associated With ears2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
Domain IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain
Domain IPR033910 Glutamyl-tRNA synthetase
Domain IPR045462 Aminoacyl-tRNA synthetase, class I, anticodon-binding
Family IPR000924 Glutamyl/glutaminyl-tRNA synthetase
Family IPR004527 Glutamate-tRNA ligase, bacterial/mitochondrial
Homologous_superfamily IPR008925 Aminoacyl-tRNA synthetase, class I, anticodon-binding superfamily
Homologous_superfamily IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Homologous_superfamily IPR020751 Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2
Domain Details Per Protein
Protein Length Aminoacyl-tRNA synthetase, class I, anticodon-binding Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 Aminoacyl-tRNA synthetase, class I, anticodon-binding superfamily Aminoacyl-tRNA synthetase, class I, conserved site Glutamate-tRNA ligase, bacterial/mitochondrial Glutamyl/glutaminyl-tRNA synthetase Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain Glutamyl-tRNA synthetase Rossmann-like alpha/beta/alpha sandwich fold
UniProtKB:A0A0G2KJV1 503
UniProtKB:Q0P499 503
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations