Gene
arrb1
- ID
- ZDB-GENE-060824-1
- Name
- arrestin, beta 1
- Symbol
- arrb1 Nomenclature History
- Previous Names
-
- arrdc1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor binding activity. Acts upstream of or within several processes, including endothelial to hematopoietic transition; regulation of microglial cell activation; and regulation of signal transduction. Predicted to be located in several cellular components, including clathrin-coated pit; cytoplasmic vesicle; and pseudopodium. Predicted to be active in cytoplasm. Is expressed in neural rod. Orthologous to human ARRB1 (arrestin beta 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Arrestin | Arrestin, conserved site | Arrestin C-terminal-like domain | Arrestin-like, C-terminal | Arrestin-like, N-terminal | Arrestin, N-terminal | Immunoglobulin E-set |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5XJ55 | InterPro | 157 | |||||||
| UniProtKB:C3PTE8 | InterPro | 418 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001159822 (1) | 1621 nt | ||
| Genomic | GenBank:FO704791 (1) | 93278 nt | ||
| Polypeptide | UniProtKB:C3PTE8 (1) | 418 aa |
- Hsu, P.J., Wang, H.D., Tseng, Y.C., Pan, S.W., Sampurna, B.P., Jong, Y.J., Yuh, C.H. (2021) L-Carnitine ameliorates congenital myopathy in a tropomyosin 3 de novo mutation transgenic zebrafish. Journal of Biomedical Science. 28:8
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Kossack, M., Hein, S., Juergensen, L., Siragusa, M., Benz, A., Katus, H.A., Most, P., Hassel, D. (2017) Induction of cardiac dysfunction in developing and adult zebrafish by chronic isoproterenol stimulation. Journal of Molecular and Cellular Cardiology. 108:95-105
- Li, Y., Du, X., Pei, G., Du, J., Zhao, J. (2016) β-Arrestin1 Regulates Morphology and Dynamics of Microglia in Zebrafish in Vivo. The European journal of neuroscience. 43(2):131-8
- Burczyk, M.S., Burkhalter, M.D., Blätte, T., Matysik, S., Caron, M.G., Barak, L.S., Philipp, M. (2015) Phenotypic Regulation of the Sphingosine 1-Phosphate Receptor Miles Apart by G Protein-Coupled Receptor Kinase 2. Biochemistry. 54(3):765-75
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kok, F.O., Shin, M., Ni, C., Gupta, A., Grosse, A.S., van Impel, A., Kirchmaier, B.C., Peterson-Maduro, J., Kourkoulis, G., Male, I., DeSantis, D.F., Sheppard-Tindell, S., Ebarasi, L., Betsholtz, C., Schulte-Merker, S., Wolfe, S.A., Lawson, N.D. (2015) Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish. Developmental Cell. 32(1):97-108
- Zhang, P., He, Q., Chen, D., Liu, W., Wang, L., Zhang, C., Ma, D., Li, W., Liu, B., Liu, F. (2015) G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition. Cell Research. 25:1093-107
- Ferreira, T., Wilson, S.R., Choi, Y.G., Risso, D., Dudoit, S., Speed, T.P., Ngai, J. (2014) Silencing of Odorant Receptor Genes by G Protein βγ Signaling Ensures the Expression of One Odorant Receptor per Olfactory Sensory Neuron. Neuron. 81(4):847-59
- Mahabaleshwar, H., Tarbashevich, K., Nowak, M., Brand, M., and Raz, E. (2012) beta-arrestin control of late endosomal sorting facilitates decoy receptor function and chemokine gradient formation. Development (Cambridge, England). 139(16):2897-2902
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