Gene
her8.2
- ID
- ZDB-GENE-060815-4
- Name
- hairy-related 8.2
- Symbol
- her8.2 Nomenclature History
- Previous Names
-
- Hes8 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in gill; heart; liver; and telencephalon.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Hairy and Enhancer of Split/HEY-related | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Orange domain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B3L0 | InterPro | 205 | ||||
| UniProtKB:A0A8M1NTZ6 | InterPro | 211 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
her8.2-201
(1)
|
Ensembl | 1,046 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-61A15 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001166166 (1) | 1046 nt | ||
| Genomic | GenBank:CR513781 (1) | 158040 nt | ||
| Polypeptide | UniProtKB:A0A8M1NTZ6 (1) | 211 aa |
No data available
- Chen, H.Y., Huang, Y.C., Yeh, T.H., Chang, C.W., Shen, Y.J., Chen, Y.C., Sun, M.Q., Cheng, Y.C. (2024) Dtx2 deficiency induces ependymo-radial glial cell proliferation and improves spinal cord motor function recovery. Stem cells and development. 33(19-20):540-550
- Chen, Y.C., Hsieh, F.Y., Chang, C.W., Sun, M.Q., Cheng, Y.C. (2024) Temporal and Spatial Variations in Zebrafish Hairy/E(spl) Gene Expression in Response to Mib1-Mediated Notch Signaling During Neurodevelopment. International Journal of Molecular Sciences. 25(17):
- Kuretani, A., Yamamoto, T., Taira, M., Michiue, T. (2021) Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs. BMC ecology and evolution. 21:147
- Huang, V., Butler, A.A., Lubin, F.D. (2019) Telencephalon transcriptome analysis of chronically stressed adult zebrafish. Scientific Reports. 9:1379
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Zhou, M., Yan, J., Ma, Z., Zhou, Y., Abbood, N.N., Liu, J., Su, L., Jia, H., and Guo, A.Y. (2012) Comparative and Evolutionary Analysis of the HES/HEY Gene Family Reveal Exon/Intron Loss and Teleost Specific Duplication Events. PLoS One. 7(7):e40649
- Chung, P.C., Lin, W.S., Scotting, P.J., Hsieh, F.Y., Wu, H.L., and Cheng, Y.C. (2011) Zebrafish her8a is activated by Su(H)-dependent Notch signaling and is essential for the inhibition of neurogenesis. PLoS One. 6(4):e19394
- Wang, Y., Chen, K., Yao, Q., Zheng, X., and Yang, Z. (2009) Phylogenetic Analysis of Zebrafish Basic Helix-Loop-Helix Transcription Factors. Journal of molecular evolution. 68(6):629-640
- Gajewski, M., Elmasri, H., Girschick, M., Sieger, D., and Winkler, C. (2006) Comparative analysis of her genes during fish somitogenesis suggests a mouse/chick-like mode of oscillation in medaka. Development genes and evolution. 216(6):315-332
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