Gene
gtf3c5
- ID
- ZDB-GENE-060810-66
- Name
- general transcription factor IIIC, polypeptide 5
- Symbol
- gtf3c5 Nomenclature History
- Previous Names
-
- im:7156509
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to contribute to RNA polymerase III type 1 promoter sequence-specific DNA binding activity and RNA polymerase III type 2 promoter sequence-specific DNA binding activity. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIIIC complex. Orthologous to human GTF3C5 (general transcription factor IIIC subunit 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7156509 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Iwata-Otsubo et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa44960 | Allele with one point mutation | Unknown | Unknown | ENU |
1 - 1 of 1
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gtf3c5 | Iwata-Otsubo et al., 2024 | |
| CRISPR2-gtf3c5 | Iwata-Otsubo et al., 2024 |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR019136 | Transcription factor IIIC subunit 5, HTH domain |
| Domain | IPR041499 | Transcription factor IIIC subunit Tfc1/Sfc1, triple barrel domain |
| Family | IPR040454 | Transcription factor IIIC subunit Tfc1/Sfc1 |
| Homologous_superfamily | IPR042536 | TFIIIC, subcomplex tauA subunit Sfc1, triple barrel domain superfamily |
1 - 4 of 4
Domain Details Per Protein
| Protein | Additional Resources | Length | TFIIIC, subcomplex tauA subunit Sfc1, triple barrel domain superfamily | Transcription factor IIIC subunit 5, HTH domain | Transcription factor IIIC subunit Tfc1/Sfc1 | Transcription factor IIIC subunit Tfc1/Sfc1, triple barrel domain |
|---|---|---|---|---|---|---|
| UniProtKB:E7EZ29 | InterPro | 529 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gtf3c5-201
(1)
|
Ensembl | 1,856 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-6P15 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7156509 | Thisse et al., 2004 |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_688483 (1) | 1791 nt | ||
| Genomic | GenBank:FP015918 (2) | 65505 nt | ||
| Polypeptide | UniProtKB:E7EZ29 (1) | 529 aa |
- Iwata-Otsubo, A., Skraban, C.M., Yoshimura, A., Sakata, T., Alves, C.A.P., Fiordaliso, S.K., Kuroda, Y., Vengoechea, J., Grochowsky, A., Ernste, P., Lulis, L., Nesbitt, A., Tayoun, A.A., Gray, C., Towne, M.C., Radtke, K., Normand, E.A., Rhodes, L., Seiler, C., Shirahige, K., Izumi, K. (2024) Biallelic variants in GTF3C5, a regulator of RNA polymerase III-mediated transcription, cause a multisystem developmental disorder. Human genetics. 143(3):437-453
- Tang, S.L., Liang, X.F., He, S., Li, L., Alam, M.S., Wu, J. (2022) Comparative Study of the Molecular Characterization, Evolution, and Structure Modeling of Digestive Lipase Genes Reveals the Different Evolutionary Selection Between Mammals and Fishes. Frontiers in genetics. 13:909091
- Wu, S.Y., Yang, W.Y., Cheng, C.C., Lin, K.H., Sampurna, B.P., Chan, S.M., Yuh, C.H. (2020) Low molecular weight fucoidan inhibits hepatocarcinogenesis and nonalcoholic fatty liver disease in zebrafish via ASGR/STAT3/HNF4A signaling. Clinical and translational medicine. 10:e252
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
1 - 4 of 4
Show