Gene

mlh3

ID
ZDB-GENE-060810-45
Name
mutL homolog 3 (E. coli)
Symbol
mlh3 Nomenclature History
Previous Names
  • im:7152582 (1)
  • si:dkey-31b16.12 (1)
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to have ATPase activity. Predicted to be involved in mismatch repair. Predicted to localize to mismatch repair complex. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal cancer; endometrial cancer; and hereditary nonpolyposis colorectal cancer type 7. Orthologous to human MLH3 (mutL homolog 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mlh3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
colorectal cancer Alliance Colorectal cancer, somatic 114500
endometrial cancer Alliance {Endometrial cancer, susceptibility to} 608089
hereditary nonpolyposis colorectal cancer type 7 Alliance Colorectal cancer, hereditary nonpolyposis, type 7 614385
Associated With mlh3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations