Gene
wdr35
- ID
- ZDB-GENE-060810-148
- Name
- WD repeat domain 35
- Symbol
- wdr35 Nomenclature History
- Previous Names
-
- im:7159945 (1)
- si:ch211-206k20.4
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Acts upstream of or within cilium assembly. Predicted to be located in centrosome; ciliary basal body; and cytoplasm. Predicted to be part of intraciliary transport particle A. Predicted to be active in axoneme. Is expressed in head and post-vent region. Human ortholog(s) of this gene implicated in Ellis-Van Creveld syndrome; cranioectodermal dysplasia 2; and short-rib thoracic dysplasia 7 with or without polydactyly. Orthologous to human WDR35 (WD repeat domain 35).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7159945 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Stawicki et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa14117 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa22338 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa35532 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa42238 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
w150 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 5 of 5
Show
No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
cranioectodermal dysplasia 2 | Alliance | Cranioectodermal dysplasia 2 | 613610 |
short-rib thoracic dysplasia 7 with or without polydactyly | Alliance | Short-rib thoracic dysplasia 7 with or without polydactyly | 614091 |
1 - 2 of 2
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | IFT121-like, zinc finger domain | IFT80/172/WDR35, TPR domain | Intraflagellar transport protein 122/121 homolog | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily | WDR35, second beta-propeller domain | WDR35/TULP4, N-terminal | WD repeat protein 35 |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9Q9T9 | InterPro | 1184 | |||||||||
UniProtKB:B7ZD88 | InterPro | 1203 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-206K20 | ZFIN Curated Data | |
Encodes | EST | IMAGE:7159945 | Thisse et al., 2004 |
1 - 2 of 2
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001145589 (1) | 4088 nt | ||
Genomic | GenBank:AL935163 (1) | 158350 nt | ||
Polypeptide | UniProtKB:B7ZD88 (1) | 1203 aa |
- Lv, Y., Li, J., Yu, S., Zhang, Y., Hu, H., Sun, K., Jia, D., Han, Y., Tu, J., Huang, Y., Liu, X., Zhang, X., Gao, P., Chen, X., Shaw Williams, M.T., Tang, Z., Shu, X., Liu, M., Ren, X. (2024) The splicing factor Prpf31 is required for hematopoietic stem and progenitor cell expansion during zebrafish embryogenesis. The Journal of biological chemistry. 300(3):105772
- Alexandre-Moreno, S., Bonet-Fernández, J.M., Atienzar-Aroca, R., Aroca-Aguilar, J.D., Escribano, J. (2021) Null cyp1b1 Activity in Zebrafish Leads to Variable Craniofacial Defects Associated with Altered Expression of Extracellular Matrix and Lipid Metabolism Genes. International Journal of Molecular Sciences. 22(12):
- Li, J., Liu, F., Lv, Y., Sun, K., Zhao, Y., Reilly, J., Zhang, Y., Tu, J., Yu, S., Liu, X., Qin, Y., Huang, Y., Gao, P., Jia, D., Chen, X., Han, Y., Shu, X., Luo, D., Tang, Z., Liu, M. (2021) Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing. Nucleic acids research. 49(4):2027-2043
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Stawicki, T.M., Hernandez, L., Esterberg, R., Linbo, T., Owens, K.N., Shah, A.N., Thapa, N., Roberts, B., Moens, C.B., Rubel, E.W., Raible, D.W. (2016) Cilia-Associated Genes Play Differing Roles in Aminoglycoside-Induced Hair Cell Death in Zebrafish. G3 (Bethesda). 6(7):2225-35
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Madgwick, A., Fort, P., Hanson, P.S., Thibault, P., Gaudreau, M.C., Lutfalla, G., Möröy, T., Abou Elela, S., Chaudhry, B., Elliott, D.J., Morris, C.M., Venables, J.P. (2015) Neural Differentiation Modulates the Vertebrate Brain Specific Splicing Program. PLoS One. 10:e0125998
- Tsai, H.Y., Hamilton, A., Tinch, A.E., Guy, D.R., Gharbi, K., Stear, M.J., Matika, O., Bishop, S.C., Houston, R.D. (2015) Genome wide association and genomic prediction for growth traits in juvenile farmed Atlantic salmon using a high density SNP array. BMC Genomics. 16:969
1 - 8 of 8
Show