ZFIN is now using GRCz12tu for Genomic Data
Gene
mgst2
- ID
- ZDB-GENE-060616-94
- Name
- microsomal glutathione S-transferase 2
- Symbol
- mgst2 Nomenclature History
- Previous Names
-
- zgc:136570
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable glutathione peroxidase activity; glutathione transferase activity; and leukotriene-C4 synthase activity. Predicted to be involved in leukotriene biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum and nuclear envelope. Is expressed in brain; gill; liver; and pleuroperitoneal region. Orthologous to human MGST2 (microsomal glutathione S-transferase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR001129 | Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein |
| Family | IPR001446 | 5-lipoxygenase-activating protein |
| Family | IPR050997 | Membrane-associated proteins in eicosanoid and glutathione metabolism |
| Homologous_superfamily | IPR023352 | Membrane associated eicosanoid/glutathione metabolism-like domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | 5-lipoxygenase-activating protein | Membrane associated eicosanoid/glutathione metabolism-like domain superfamily | Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein | Membrane-associated proteins in eicosanoid and glutathione metabolism |
|---|---|---|---|---|---|---|
| UniProtKB:Q1ECY7 | InterPro | 136 | ||||
| UniProtKB:A0AB32T5L6 | InterPro | 136 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-113D11 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136570 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045302 (1) | 929 nt | ||
| Genomic | GenBank:BX005077 (2) | 127560 nt | ||
| Polypeptide | UniProtKB:A0AB32T5L6 (1) | 136 aa |
- Madera, D., Alonso-Gómez, A., Delgado, M.J., Valenciano, A.I., Alonso-Gómez, Á.L. (2023) Gene Characterization of Nocturnin Paralogues in Goldfish: Full Coding Sequences, Structure, Phylogeny and Tissue Expression. International Journal of Molecular Sciences. 25(1):
- Barthelson, K., Baer, L., Dong, Y., Hand, M., Pujic, Z., Newman, M., Goodhill, G.J., Richards, R.I., Pederson, S.M., Lardelli, M. (2021) Zebrafish Chromosome 14 Gene Differential Expression in the fmr1hu2787 Model of Fragile X Syndrome. Frontiers in genetics. 12:625466
- Bao, Z., Zhao, Y., Wu, A., Lou, Z., Lu, H., Yu, Q., Fu, Z., Jin, Y. (2020) Sub-chronic carbendazim exposure induces hepatic glycolipid metabolism disorder accompanied by gut microbiota dysbiosis in adult zebrafish (Daino rerio). The Science of the total environment. 739:140081
- Kasper, D.M., Hintzen, J., Wu, Y., Ghersi, J.J., Mandl, H.K., Salinas, K.E., Armero, W., He, Z., Sheng, Y., Xie, Y., Heindel, D.W., Park, E.J., Sessa, W.C., Mahal, L.K., Lebrilla, C., Hirschi, K.K., Nicoli, S. (2020) The N-glycome regulates the endothelial-to-hematopoietic transition. Science (New York, N.Y.). 370:1186-1191
- Huang, L., Urasaki, A., Inagaki, N. (2019) Rab33a and Rab33ba mediate the outgrowth of forebrain commissural axons in the zebrafish brain. Scientific Reports. 9:1799
- Duan, J., Yu, Y., Li, Y., Jing, L., Yang, M., Wang, J., Li, Y., Zhou, X., Miller, M.R., Sun, Z. (2017) Comprehensive understanding of PM2.5 on gene and microRNA expression patterns in zebrafish (Danio rerio) model.. The Science of the total environment. 586:666-674
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Glisic, B., Mihaljevic, I., Popovic, M., Zaja, R., Loncar, J., Fent, K., Kovacevic, R., Smital, T. (2015) Characterization of glutathione-S-transferases in zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 158C:50-62
- Timme-Laragy, A.R., Goldstone, J.V., Imhoff, B.R., Stegeman, J.J., Hahn, M.E., and Hansen, J.M. (2013) Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo. Free radical biology & medicine. 65:89-101
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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