Gene
ttll3
- ID
- ZDB-GENE-060616-182
- Name
- tubulin tyrosine ligase-like family, member 3
- Symbol
- ttll3 Nomenclature History
- Previous Names
-
- zgc:136840
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables tubulin-glycine ligase activity. Involved in axoneme assembly and protein polyglycylation. Acts upstream of or within cilium movement. Located in cilium. Is expressed in lateral line; peripheral olfactory organ; and pronephros. Orthologous to several human genes including TTLL3 (tubulin tyrosine ligase like 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Pathak et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ttll3 | Sun et al., 2024 | |
| MO1-ttll3 | N/A | (2) |
| MO2-ttll3 | N/A | Wloga et al., 2009 |
| MO3-ttll3 | N/A | Pathak et al., 2011 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Tubulin tyrosine ligase-like monoglycylase | Tubulin-tyrosine ligase/Tubulin polyglutamylase |
|---|---|---|---|---|
| UniProtKB:Q1ECV4 | InterPro | 771 | ||
| UniProtKB:A0A8M3BAI3 | InterPro | 422 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-28N18 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136840 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045305 (1) | 2541 nt | ||
| Genomic | GenBank:BX936393 (1) | 204873 nt | ||
| Polypeptide | UniProtKB:Q1ECV4 (1) | 771 aa |
- Sun, Y., Chen, Z., Jin, M., Xie, H., Zhao, C. (2024) Ciliary length regulation by intraflagellar transport in zebrafish. eLIFE. 13:
- Fouchécourt, S., Picolo, F., Elis, S., Lécureuil, C., Thélie, A., Govoroun, M., Brégeon, M., Papillier, P., Lareyre, J.J., Monget, P. (2019) An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse. BMC Evolutionary Biology. 19:137
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Pathak, N., Austin, C.A., and Drummond, I.A. (2011) Tubulin tyrosine ligase like genes TTLL3 and TTLL6 maintain zebrafish cilia structure and motility. The Journal of biological chemistry. 286(13):11685-11695
- Wloga, D., Webster, D.M., Rogowski, K., Bré, M.H., Levilliers, N., Jerka-Dziadosz, M., Janke, C., Dougan, S.T., and Gaertig, J. (2009) TTLL3 Is a tubulin glycine ligase that regulates the assembly of cilia. Developmental Cell. 16(6):867-876
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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