Gene
prkg2
- ID
- ZDB-GENE-060531-80
- Name
- protein kinase cGMP-dependent 2
- Symbol
- prkg2 Nomenclature History
- Previous Names
-
- si:dkey-18e17.2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; cGMP binding activity; and cGMP-dependent protein kinase activity. Predicted to be involved in protein phosphorylation. Is expressed in integument; nervous system; and pleuroperitoneal region. Orthologous to human PRKG2 (protein kinase cGMP-dependent 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Li et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acromesomelic dysplasia-4 | Alliance | Acromesomelic dysplasia 4 | 619636 |
| Spondylometaphyseal dysplasia, Pagnamenta type | 619638 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR018488 | Cyclic nucleotide-binding, conserved site |
| Domain | IPR000595 | Cyclic nucleotide-binding domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR035014 | cGMP-dependent protein kinase, catalytic domain |
| Family | IPR002374 | cGMP-dependent kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR014710 | RmlC-like jelly roll fold |
| Homologous_superfamily | IPR018490 | Cyclic nucleotide-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | AGC-kinase, C-terminal | cGMP-dependent kinase | cGMP-dependent protein kinase, catalytic domain | Cyclic nucleotide-binding, conserved site | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | RmlC-like jelly roll fold | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9Q2S7
|
769 | |||||||||||
|
UniProtKB:A2AVJ3
|
768 |
Interactions and Pathways
No data available
Plasmids
No data available