Gene

nr3c2

ID
ZDB-GENE-060531-23
Name
nuclear receptor subfamily 3, group C, member 2
Symbol
nr3c2 Nomenclature History
Previous Names
  • mineralocorticoid receptor (1)
  • MR (1)
  • mr (1)
  • si:ch211-189l17.1
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Enables steroid hormone binding activity and steroid hormone receptor activity. Acts upstream of or within cellular response to cortisol stimulus and multicellular organismal response to stress. Predicted to be located in nucleus. Is expressed in several structures, including blood; eye; heart; liver; and pleuroperitoneal region. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1 and pseudohypoaldosteronism. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
21 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nr3c2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant pseudohypoaldosteronism type 1 Alliance Pseudohypoaldosteronism type I, autosomal dominant 177735
Hypertension, early-onset, autosomal dominant, with exacerbation in pregnancy 605115
Associated With nr3c2 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Family IPR001723 Nuclear hormone receptor
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:Q1L689 352
UniProtKB:A0A0R4IQ49 587
UniProtKB:A6YIH7 970
UniProtKB:A0A0R4ICJ8 383
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations