ZFIN is now using GRCz12tu for Genomic Data
Gene
pcsk5a
- ID
- ZDB-GENE-060531-130
- Name
- proprotein convertase subtilisin/kexin type 5a
- Symbol
- pcsk5a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable serine-type endopeptidase activity. Acts upstream of or within anterior lateral line development and neuromast development. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi membrane and trans-Golgi network. Is expressed in several structures, including eye; lateral line system; liver; otic vesicle; and pleuroperitoneal region. Orthologous to human PCSK5 (proprotein convertase subtilisin/kexin type 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Chitramuthu et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR022398 | Peptidase S8, subtilisin, His-active site |
| Active_site | IPR023827 | Peptidase S8, subtilisin, Asp-active site |
| Active_site | IPR023828 | Peptidase S8, subtilisin, Ser-active site |
| Domain | IPR000209 | Peptidase S8/S53 domain |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001368 | TNFR/NGFR cysteine-rich region |
| Domain | IPR002884 | P domain |
| Domain | IPR032778 | Growth factor receptor domain 4 |
| Domain | IPR032815 | Peptidase S8, pro-domain |
| Domain | IPR034182 | Kexin/furin catalytic domain |
| Family | IPR015500 | Peptidase S8, subtilisin-related |
| Homologous_superfamily | IPR008979 | Galactose-binding-like domain superfamily |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR036852 | Peptidase S8/S53 domain superfamily |
| Homologous_superfamily | IPR038466 | Peptidase S8, pro-domain superfamily |
| Repeat | IPR006212 | Furin-like repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like domain | Furin-like repeat | Galactose-binding-like domain superfamily | Growth factor receptor cysteine-rich domain superfamily | Growth factor receptor domain 4 | Kexin/furin catalytic domain | P domain | Peptidase S8, pro-domain | Peptidase S8, pro-domain superfamily | Peptidase S8/S53 domain | Peptidase S8/S53 domain superfamily | Peptidase S8, subtilisin, Asp-active site | Peptidase S8, subtilisin, His-active site | Peptidase S8, subtilisin-related | Peptidase S8, subtilisin, Ser-active site | TNFR/NGFR cysteine-rich region |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q4U3 | InterPro | 1867 | ||||||||||||||||
| UniProtKB:A0A8M1RIN1 | InterPro | 1867 | ||||||||||||||||
| UniProtKB:A0AB32TI02 | InterPro | 1157 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pcsk5a-201
(1)
|
Ensembl | 5,466 nt | ||
| mRNA |
pcsk5a-202
(1)
|
Ensembl | 3,495 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers