Gene
dab1a
- ID
- ZDB-GENE-060528-1
- Name
- DAB adaptor protein 1a
- Symbol
- dab1a Nomenclature History
- Previous Names
-
- dab1
- si:dkey-242m13.1
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to be involved in neuron migration. Predicted to act upstream of or within cell differentiation. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; immature eye; pronephric duct; retina; and spinal cord interneuron. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 37. Orthologous to human DAB1 (DAB adaptor protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| dab1a_unrecovered | Allele with one point mutation | Unknown | Unknown | ENU | |
| fh304 | Allele with one point mutation | Unknown | Unknown | ENU | |
| ic3031 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa14868 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa15478 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa29312 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa36974 | Allele with one point mutation | Unknown | Missense, Splice Site | ENU | |
| sa36975 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa43385 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa45689 | Allele with one point mutation | Unknown | Missense, Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spinocerebellar ataxia type 37 | Alliance | Spinocerebellar ataxia 37 | 615945 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Disabled homolog 1/2, sulfatide-binding motif | Disabled, phosphotyrosine-binding domain | PH-like domain superfamily | PTB/PI domain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AKN7 | InterPro | 571 | ||||
| UniProtKB:A0A8M3AW18 | InterPro | 597 | ||||
| UniProtKB:A0A8M2BHH7 | InterPro | 576 | ||||
| UniProtKB:F1Q6J4 | InterPro | 565 | ||||
| UniProtKB:A2BEF7 | InterPro | 537 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-136O23 | ZFIN Curated Data | |
| Contained in | BAC | CH211-232I5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-242M13 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001040685 (1) | 9060 nt | ||
| Genomic | GenBank:BX085194 (2) | 169865 nt | ||
| Polypeptide | UniProtKB:A0A8M3AW18 (1) | 597 aa |
- Nimura, T., Itoh, T., Hagio, H., Hayashi, T., Di Donato, V., Takeuchi, M., Itoh, T., Inoguchi, F., Sato, Y., Yamamoto, N., Katsuyama, Y., Del Bene, F., Shimizu, T., Hibi, M. (2019) Role of Reelin in cell positioning in the cerebellum and the cerebellum-like structure in zebrafish. Developmental Biology. 455(2):393-408
- Sharma, D., Sehgal, P., Mathew, S., Vellarikkal, S.K., Singh, A.R., Kapoor, S., Jayarajan, R., Scaria, V., Sivasubbu, S. (2019) A genome-wide map of circular RNAs in adult zebrafish. Scientific Reports. 9:3432
- Vecchia, E.D., Donato, V.D., Young, A.M.J., Bene, F.D., Norton, W.H.J. (2019) Reelin Signaling Controls the Preference for Social Novelty in Zebrafish. Frontiers in behavioral neuroscience. 13:214
- Di Donato, V., De Santis, F., Albadri, S., Auer, T.O., Duroure, K., Charpentier, M., Concordet, J.P., Gebhardt, C., Del Bene, F. (2018) An Attractive Reelin Gradient Establishes Synaptic Lamination in the Vertebrate Visual System. Neuron. 97(5):1049-1062.e6
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Imai, H., Oomiya, Y., Kikkawa, S., Shoji, W., Hibi, M., Terashima, T., and Katsuyama, Y. (2012) Dynamic changes in the gene expression of zebrafish Reelin receptors during embryogenesis and hatching period. Development, growth & differentiation. 54(2):253-263
- Herrero-Turrión, M.J., Velasco, A., Arevalo, R., Aijón, J., and Lara, J.M. (2010) Characterisation and differential expression during development of a duplicate Disabled-1 (Dab1) gene from zebrafish. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 155(3):217-229
- Costagli, A., Felice, B., Guffanti, A., Wilson, S.W., and Mione, M. (2006) Identification of alternatively spliced dab1 isoforms in zebrafish. Development genes and evolution. 216(6):291-299
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