Gene
pappab
- ID
- ZDB-GENE-060526-71
- Name
- pregnancy-associated plasma protein A, pappalysin 1b
- Symbol
- pappab Nomenclature History
- Previous Names
-
- si:ch211-196f15.1
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables peptidase activity. Acts upstream of or within chordate embryonic development. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; muscle; nervous system; pleuroperitoneal region; and skeletal tissue. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human PAPPA (pappalysin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Kjaer-Sorensen et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9050 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa12988 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13003 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20569 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20570 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa25317 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33750 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44625 | Allele with one point mutation | Unknown | Unknown | ENU | |
| zf3376 | Allele with one deletion | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | LamG-like jellyroll fold | Metallopeptidase, catalytic domain superfamily | Myxococcus cysteine-rich repeat | Notch domain | Pappalysin-1/2 | Peptidase M43, pregnancy-associated plasma-A | Sushi/SCR/CCP domain | Sushi/SCR/CCP superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3ASU7 | InterPro | 1633 | |||||||||
| UniProtKB:M1WXG8 | InterPro | 1624 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pappab-201
(1)
|
Ensembl | 5,091 nt | ||
| mRNA |
pappab-202
(1)
|
Ensembl | 599 nt | ||
| mRNA |
pappab-203
(1)
|
Ensembl | 4,821 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
- Harboe, M., Kjaer-Sorensen, K., Füchtbauer, E.M., Fenton, R.A., Thomsen, J.S., Brüel, A., Oxvig, C. (2024) The metalloproteinase PAPP-A is required for IGF-dependent chondrocyte differentiation and organization. Scientific Reports. 14:2016120161
- Liu, C., Li, S., Noer, P.R., Kjaer-Sorensen, K., Juhl, A.K., Goldstein, A., Ke, C., Oxvig, C., Duan, C. (2020) The metalloproteinase Papp-aa controls epithelial cell quiescence-proliferation transition. eLIFE. 9:
- Sugden, W.W., Meissner, R., Aegerter-Wilmsen, T., Tsaryk, R., Leonard, E.V., Bussmann, J., Hamm, M.J., Herzog, W., Jin, Y., Jakobsson, L., Denz, C., Siekmann, A.F. (2017) Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. Nature cell biology. 19(6):653-665
- Kjaer-Sorensen, K., Engholm, D.H., Kamei, H., Morch, M.G., Kristensen, A.O., Zhou, J., Conover, C.A., Duan, C., and Oxvig, C. (2013) Pregnancy-associated plasma protein-A (PAPP-A) modulates early developmental rate in zebrafish independent of its proteolytic activity. The Journal of biological chemistry. 288(14):9982-92
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