Gene
clip1a
- ID
- ZDB-GENE-060526-282
- Name
- CAP-GLY domain containing linker protein 1a
- Symbol
- clip1a Nomenclature History
- Previous Names
-
- clip1
- si:dkey-273o13.1
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable microtubule plus-end binding activity. Acts upstream of or within positive regulation of microtubule polymerization. Predicted to be located in cytoplasm and microtubule. Predicted to be active in cell cortex; microtubule plus-end; and nucleus. Orthologous to human CLIP1 (CAP-Gly domain containing linker protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Weng et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Weng et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9135 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33768 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38528 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zf3909 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| zf3910 | Allele with one deletion | Unknown | Unknown | CRISPR |
1 - 5 of 5
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-clip1a | N/A | Weng et al., 2013 |
| MO2-clip1a | N/A | Weng et al., 2013 |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CAP Gly-rich domain | CAP Gly-rich domain superfamily | CLIP1, zinc knuckle |
|---|---|---|---|---|---|
| UniProtKB:A0A8M3ASW5 | InterPro | 1443 | |||
| UniProtKB:A0A8M3B021 | InterPro | 1534 | |||
| UniProtKB:A0A8M3B2Z4 | InterPro | 1537 | |||
| UniProtKB:E7F2X0 | InterPro | 1569 |
1 - 4 of 4
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
clip1a-201
(1)
|
Ensembl | 4,710 nt | ||
| mRNA |
clip1a-202
(1)
|
Ensembl | 1,366 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-273O13 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009301992 (1) | |||
| Genomic | GenBank:BX897741 (1) | 168673 nt | ||
| Polypeptide | UniProtKB:E7F2X0 (1) | 1569 aa |
- Kolas, V., Mathieu, G., Wu, Y.T., Chung, B.C. (2022) Evaluation of two gene ablation methods for the analysis of pregnenolone function in zebrafish embryonic development. Biochemical and Biophysical Research Communications. 636:84-88
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Weng, J.H., Liang, M.R., Chen, C.H., Tong, S.K., Huang, T.C., Lee, S.P., Chen, Y.R., Chen, C.T., and Chung, B.C. (2013) Pregnenolone activates CLIP-170 to promote microtubule growth and cell migration. Nature Chemical Biology. 9(10):636-42
1 - 3 of 3
Show