Gene
tmc2a
- ID
- ZDB-GENE-060526-280
- Name
- transmembrane channel-like 2a
- Symbol
- tmc2a Nomenclature History
- Previous Names
-
- si:dkey-267i17.6
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable calcium channel activity and mechanosensitive monoatomic ion channel activity. Involved in inner ear receptor cell development and lateral line development. Acts upstream of or within cellular response to mechanical stimulus and detection of mechanical stimulus involved in sensory perception of sound. Located in plasma membrane. Is expressed in inner ear and neuromast. Orthologous to human TMC2 (transmembrane channel like 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Maeda et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| cwr10 | Allele with one delins | Exon 6 | Frameshift, Premature Stop | CRISPR | |
| ihb547 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
| ihb548 | Allele with one delins | Exon 3 | Unknown | CRISPR | |
| sa11141 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa44620 | Allele with one point mutation | Unknown | Unknown | ENU | |
| vo72 | Allele with one deletion | Unknown | Unknown | TALEN | |
| zf3402 | Allele with one delins | Exon 9 | Premature Stop | CRISPR | |
| zf3403 | Allele with one deletion | Exon 9 | Premature Stop | CRISPR | |
| zf3408 | Allele with one delins | Exon 9 | Premature Stop | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tmc2a | Chou et al., 2017 | |
| CRISPR2-tmc2a | (2) | |
| CRISPR3-tmc2a | Zebrafish Nomenclature Committee |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | TMC domain | Transmembrane channel-like protein |
|---|---|---|---|---|
| UniProtKB:E7FFT2 | InterPro | 916 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-10H13 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-267I17 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001302237 (1) | |||
| Genomic | GenBank:CR383678 (1) | 198392 nt | ||
| Polypeptide | UniProtKB:E7FFT2 (1) | 916 aa |
- Smith, E.T., Sun, P., Yu, S.K., Raible, D.W., Nicolson, T. (2023) Differential expression of mechanotransduction complex genes in auditory/vestibular hair cells in zebrafish. Frontiers in molecular neuroscience. 16:12748221274822
- Sun, P., Smith, E., Nicolson, T. (2023) Transmembrane channel-like (Tmc) subunits contribute to frequency sensitivity in the zebrafish utricle. The Journal of neuroscience : the official journal of the Society for Neuroscience. 44(1):
- Li, X.D., Tu, H.W., Hu, K.Q., Liu, Y.G., Mao, L.N., Wang, F.Y., Qu, H.Y., Chen, Q. (2021) Effects of Toluene on the Development of the Inner Ear and Lateral Line Sensory System of Zebrafish. Biomedical and environmental sciences : BES. 34:110-118
- Zhu, S., Chen, Z., Wang, H., McDermott, B.M. (2021) Tmc Reliance Is Biased by the Hair Cell Subtype and Position Within the Ear. Frontiers in cell and developmental biology. 8:570486
- Chen, Z., Zhu, S., Kindig, K., Wang, S., Chou, S.W., Davis, R.W., Dercoli, M.R., Weaver, H., Stepanyan, R., McDermott, B.M. (2020) Tmc proteins are essential for zebrafish hearing where Tmc1 is not obligatory. Human molecular genetics. 29(12):2004-2021
- Smith, E.T., Pacentine, I., Shipman, A., Hill, M., Nicolson, T. (2020) Disruption of tmc1/2a/2b genes in zebrafish reveals subunit requirements in subtypes of inner ear hair cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 40(23):4457-4468
- Barta, C.L., Liu, H., Chen, L., Giffen, K.P., Li, Y., Kramer, K.L., Beisel, K.W., He, D.Z. (2018) RNA-seq transcriptomic analysis of adult zebrafish inner ear hair cells. Scientific data. 5:180005
- Chou, S.W., Chen, Z., Zhu, S., Davis, R.W., Hu, J., Liu, L., Fernando, C.A., Kindig, K., Brown, W.C., Stepanyan, R., McDermott, B.M. (2017) A molecular basis for water motion detection by the mechanosensory lateral line of zebrafish. Nature communications. 8:2234
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Erickson, T., Nicolson, T. (2015) Identification of sensory hair-cell transcripts by thiouracil-tagging in zebrafish. BMC Genomics. 16:842
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