Gene
klf9
- ID
- ZDB-GENE-060526-244
- Name
- Kruppel like factor 9
- Symbol
- klf9 Nomenclature History
- Previous Names
-
- BTEB (1)
- si:dkey-201c13.3
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within T cell proliferation; erythrocyte maturation; and regulation of oxygen metabolic process. Predicted to be located in nucleus. Is expressed in forebrain; hindbrain; and midbrain. Orthologous to human KLF9 (KLF transcription factor 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| mdi5 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR | |
| mdi6Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| sa9385 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11647 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40427 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 5 of 5
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-klf9 | (2) | |
| CRISPR2-klf9 | Gans et al., 2021 | |
| CRISPR3-klf9 | Gans et al., 2021 | |
| MO1-klf9 | N/A | Zhang et al., 2017 |
1 - 4 of 4
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|
| UniProtKB:A2BGS7 | InterPro | 216 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-201C13 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194192 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194193 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128729 (1) | 1360 nt | ||
| Genomic | GenBank:BX511001 (1) | 53155 nt | ||
| Polypeptide | UniProtKB:A2BGS7 (1) | 216 aa |
- Drepanos, L., Gans, I.M., Grendler, J., Guitar, S., Fuqua, J.H., Maki, N.J., Tilden, A.R., Graber, J.H., Coffman, J.A. (2023) Loss of Krüppel-like factor 9 deregulates both physiological gene expression and development. Scientific Reports. 13:1223912239
- Dinarello, A., Tesoriere, A., Martini, P., Fontana, C.M., Volpato, D., Badenetti, L., Terrin, F., Facchinello, N., Romualdi, C., Carnevali, O., Dalla Valle, L., Argenton, F. (2022) Zebrafish Mutant Lines Reveal the Interplay between nr3c1 and nr3c2 in the GC-Dependent Regulation of Gene Transcription. International Journal of Molecular Sciences. 23(5):
- Yu, F., Luo, H.R., Cui, X.F., Wu, Y.J., Li, J.L., Feng, W.R., Tang, Y.K., Su, S.Y., Xiao, J., Hou, Z.S., Xu, P. (2022) Changes in aggression and locomotor behaviors in response to zinc is accompanied by brain cell heterogeneity and metabolic and circadian dysregulation of the brain-liver axis. Ecotoxicology and environmental safety. 248:114303
- Blanc, M., Antczak, P., Cousin, X., Grunau, C., Scherbak, N., Rüegg, J., Keiter, S.H. (2021) The insecticide permethrin induces transgenerational behavioral changes linked to transcriptomic and epigenetic alterations in zebrafish (Danio rerio). The Science of the total environment. 779:146404
- Gans, I.M., Grendler, J., Babich, R., Jayasundara, N., Coffman, J.A. (2021) Glucocorticoid-Responsive Transcription Factor Krüppel-Like Factor 9 Regulates fkbp5 and Metabolism. Frontiers in cell and developmental biology. 9:727037
- Walter, K.M., Singh, L., Singh, V., Lein, P.J. (2021) Investigation of NH3 as a selective thyroid hormone receptor modulator in larval zebrafish (Danio rerio). Neurotoxicology. 84:96-104
- Gans, I., Hartig, E.I., Zhu, S., Tilden, A.R., Hutchins, L.N., Maki, N.J., Graber, J.H., Coffman, J.A. (2020) Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity. Scientific Reports. 10:11415
- Hartig, E.I., Zhu, S., King, B.L., Coffman, J.A. (2020) Chronic cortisol exposure in early development leads to neuroendocrine dysregulation in adulthood. BMC research notes. 13:366
- Hu, Z., Dang, Y., Liu, C., Zhou, L., Liu, H. (2019) Acute exposure to ustiloxin A affects growth and development of early life zebrafish, Danio rerio. Chemosphere. 226:851-857
- Walter, K.M., Dach, K., Hayakawa, K., Giersiefer, S., Heuer, H., Lein, P.J., Fritsche, E. (2019) Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison. PLoS One. 14:e0221230
1 - 10 of 20
Show