Gene
plpp3
- ID
- ZDB-GENE-060526-241
- Name
- phospholipid phosphatase 3
- Symbol
- plpp3 Nomenclature History
- Previous Names
-
- lpp3 (1)
- ppap2b
- si:dkey-19f4.1
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable phosphatidate phosphatase activity. Predicted to be involved in several processes, including cell-cell adhesion; phospholipid dephosphorylation; and phospholipid metabolic process. Predicted to be located in several cellular components, including basolateral plasma membrane; bounding membrane of organelle; and membrane raft. Predicted to be active in plasma membrane. Is expressed in somite and vasculature. Orthologous to human PLPP3 (phospholipid phosphatase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Paksa et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-plpp3 | Paksa et al., 2016 | |
CRISPR2-plpp3 | Paksa et al., 2016 | |
CRISPR3-plpp3 | Paksa et al., 2016 | |
CRISPR4-plpp3 | Paksa et al., 2016 | |
MO1-plpp3 | N/A | Paksa et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Phosphatidate (PA) phosphatase-related | Phosphatidic acid phosphatase type 2/haloperoxidase | Phosphatidic acid phosphatase type 2/haloperoxidase superfamily |
---|---|---|---|---|---|
UniProtKB:A0A8M1RMU0 | InterPro | 311 | |||
UniProtKB:F1Q6K0 | InterPro | 312 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-19F4 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_001919526 (1) | |||
Genomic | GenBank:BX649528 (2) | 205281 nt | ||
Polypeptide | UniProtKB:F1Q6K0 (1) | 312 aa |
- Malhotra, D., Shin, J., Solnica-Krezel, L., Raz, E. (2018) Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors. eLIFE. 7
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Paksa, A., Bandemer, J., Hoeckendorf, B., Razin, N., Tarbashevich, K., Minina, S., Meyen, D., Biundo, A., Leidel, S.A., Peyrieras, N., Gov, N.S., Keller, P.J., Raz, E. (2016) Repulsive cues combined with physical barriers and cell-cell adhesion determine progenitor cell positioning during organogenesis. Nature communications. 7:11288
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Cheng, W., Guo, L., Zhang, Z., Soo, H.M., Wen, C., Wu, W., and Peng, J. (2006) HNF factors form a network to regulate liver-enriched genes in zebrafish. Developmental Biology. 294(2):482-496
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