sftpbb

ID

ZDB-GENE-060526-155

Name

surfactant protein Bb

Symbol

sftpbb Nomenclature History

Previous Names

si:ch211-283h6.6
wu:fd19f07

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable methyltransferase activity. Predicted to act upstream of or within sphingolipid metabolic process. Predicted to be located in lysosome. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in lung disease (multiple); respiratory syncytial virus infectious disease; and toxic shock syndrome. Orthologous to several human genes including MEPCE (methylphosphate capping enzyme).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sftpbb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
pulmonary alveolar proteinosis	Alliance	Surfactant metabolism dysfunction, pulmonary, 1	265120

Associated With sftpbb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR007856	Saposin-like type B, region 1
Domain	IPR008138	Saposin B type, region 2
Domain	IPR008139	Saposin B type domain
Domain	IPR013087	Zinc finger C2H2-type
Family	IPR008373	Saposin
Family	IPR051428	Sphingolipid Activators and Surfactant Proteins
Homologous_superfamily	IPR011001	Saposin-like