Gene
cacna2d2b
- ID
- ZDB-GENE-060503-99
- Name
- calcium channel, voltage-dependent, alpha 2/delta subunit 2b
- Symbol
- cacna2d2b Nomenclature History
- Previous Names
-
- si:ch211-11p18.4
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable voltage-gated calcium channel activity. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated calcium channel complex. Orthologous to human CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Yu et al., 2024
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Cerebellar atrophy with seizures and variable developmental delay | 618501 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002035 | von Willebrand factor, type A |
| Domain | IPR013608 | VWA N-terminal |
| Domain | IPR013680 | Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region |
| Family | IPR051173 | Voltage-dependent calcium channel subunit alpha-2/delta |
| Homologous_superfamily | IPR036465 | von Willebrand factor A-like domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region | Voltage-dependent calcium channel subunit alpha-2/delta | von Willebrand factor A-like domain superfamily | von Willebrand factor, type A | VWA N-terminal |
|---|---|---|---|---|---|---|---|
| UniProtKB:F1R7M3 | InterPro | 1052 | |||||
| UniProtKB:A0A8M3AM54 | InterPro | 1089 | |||||
| UniProtKB:A0A8M3B5D8 | InterPro | 1075 | |||||
| UniProtKB:A0A8M3AUK1 | InterPro | 1090 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cacna2d2b-201
(1)
|
Ensembl | 3,635 nt | ||
| mRNA |
cacna2d2b-202
(1)
|
Ensembl | 3,644 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-11P18 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001089420 (1) | 3635 nt | ||
| Genomic | GenBank:AL845526 (1) | 165617 nt | ||
| Polypeptide | UniProtKB:A0A8M3AUK1 (1) | 1090 aa |
- Yu, R., Ai, N., Huang, C., Wang, D., Bian, C., Ge, W., Chong, C.M. (2024) Aspirin reduces Ponatinib-induced cardiovascular toxic phenotypes and death in zebrafish. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 180:117503117503
- Cai, W., Wang, Y., Luo, Y., Gao, L., Zhang, J., Jiang, Z., Fan, X., Li, F., Xie, Y., Wu, X., Li, Y., Yuan, W. (2023) asb5a/asb5b Double Knockout Affects Zebrafish Cardiac Contractile Function. International Journal of Molecular Sciences. 24(22):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Cardoso, J.C., Bergqvist, C.A., Felix, R.C., Larhammar, D. (2016) Corticotropin-releasing hormone family evolution: five ancestral genes remain in some lineages. Journal of molecular endocrinology. 57(1):73-86
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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