Gene
si:dkey-91m11.5
- ID
- ZDB-GENE-060503-932
- Name
- si:dkey-91m11.5
- Symbol
- si:dkey-91m11.5 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity; guanyl-nucleotide exchange factor activity; and protein serine/threonine kinase activity. Predicted to act upstream of or within intracellular signal transduction; positive regulation of GTPase activity; and protein phosphorylation. Predicted to be located in axon and dendritic spine. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; chronic myeloid leukemia; and leukemia. Orthologous to human BCR (BCR activator of RhoGEF and GTPase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001331 | Guanine-nucleotide dissociation stimulator, CDC24, conserved site |
| Domain | IPR000008 | C2 domain |
| Domain | IPR000198 | Rho GTPase-activating protein domain |
| Domain | IPR000219 | Dbl homology domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR015123 | Bcr-Abl oncoprotein oligomerisation |
| Family | IPR037769 | Abr/Bcr |
| Homologous_superfamily | IPR008936 | Rho GTPase activation protein |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
| Homologous_superfamily | IPR036481 | Bcr-Abl oncoprotein oligomerisation domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Abr/Bcr | Bcr-Abl oncoprotein oligomerisation | Bcr-Abl oncoprotein oligomerisation domain superfamily | C2 domain | C2 domain superfamily | Dbl homology (DH) domain superfamily | Dbl homology domain | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | PH-like domain superfamily | Pleckstrin homology domain | Rho GTPase-activating protein domain | Rho GTPase activation protein |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BEH2 | InterPro | 1291 | ||||||||||||
| UniProtKB:A0A8M9Q3H0 | InterPro | 1312 | ||||||||||||
| UniProtKB:B0R0B4 | InterPro | 1290 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:dkey-91m11.5-201
(1)
|
Ensembl | 4,003 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance