Gene

si:dkey-91m11.5

ID
ZDB-GENE-060503-932
Name
si:dkey-91m11.5
Symbol
si:dkey-91m11.5 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable GTPase activator activity; guanyl-nucleotide exchange factor activity; and protein serine/threonine kinase activity. Predicted to act upstream of or within intracellular signal transduction; positive regulation of GTPase activity; and protein phosphorylation. Predicted to be located in axon and dendritic spine. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; chronic myeloid leukemia; and leukemia. Orthologous to human BCR (BCR activator of RhoGEF and GTPase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With si:dkey-91m11.5 Human Ortholog
No data available
Associated With si:dkey-91m11.5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain IPR000008 C2 domain
Domain IPR000198 Rho GTPase-activating protein domain
Domain IPR000219 Dbl homology domain
Domain IPR001849 Pleckstrin homology domain
1 - 5 of 12 Show all
Domain Details Per Protein
Protein Additional Resources Length Abr/Bcr Bcr-Abl oncoprotein oligomerisation Bcr-Abl oncoprotein oligomerisation domain superfamily C2 domain C2 domain superfamily Dbl homology (DH) domain superfamily Dbl homology domain Guanine-nucleotide dissociation stimulator, CDC24, conserved site PH-like domain superfamily Pleckstrin homology domain Rho GTPase-activating protein domain Rho GTPase activation protein
UniProtKB:A0A8M2BEH2 InterPro 1291
UniProtKB:A0A8M9Q3H0 InterPro 1312
UniProtKB:B0R0B4 InterPro 1290
1 - 3 of 3
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA si:dkey-91m11.5-201 (1)
Ensembl
Ensembl 4,003 nt
ZFIN BLAST
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.