Gene
stim1a
- ID
- ZDB-GENE-060503-914
- Name
- stromal interaction molecule 1a
- Symbol
- stim1a Nomenclature History
- Previous Names
-
- si:dkey-24p1.5
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable calcium channel regulator activity and calcium ion binding activity. Predicted to be involved in intracellular calcium ion homeostasis and store-operated calcium entry. Predicted to act upstream of or within activation of store-operated calcium channel activity. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including brain; head; liver; pleuroperitoneal region; and skeletal muscle. Human ortholog(s) of this gene implicated in Stormorken syndrome; gastrointestinal system cancer (multiple); immunodeficiency 10; lung cancer; and tubular aggregate myopathy 1. Orthologous to human STIM1 (stromal interaction molecule 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la027645Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa35971 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| xt16 | Allele with one delins | Unknown | Frameshift, Premature Stop | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 10 | Alliance | Immunodeficiency 10 | 612783 |
| Stormorken syndrome | Alliance | Stormorken syndrome | 185070 |
| tubular aggregate myopathy 1 | Alliance | Myopathy, tubular aggregate, 1 | 160565 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Sterile alpha motif/pointed domain superfamily | Stromal interaction molecule | Stromal interaction molecule 1, SAM domain | Stromal interaction molecule, Orai1-activating region |
|---|---|---|---|---|---|---|
| UniProtKB:Q1LY88 | InterPro | 676 | ||||
| UniProtKB:A0A8M2BKR0 | InterPro | 781 | ||||
| UniProtKB:A0A8M2BKP3 | InterPro | 808 | ||||
| UniProtKB:A0A2R8RIM0 | InterPro | 703 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
stim1a-201
(1)
|
Ensembl | 4,416 nt | ||
| mRNA |
stim1a-202
(1)
|
Ensembl | 7,520 nt | ||
| mRNA |
stim1a-203
(1)
|
Ensembl | 2,109 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-24P1 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162007 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044799 (1) | 2934 nt | ||
| Genomic | GenBank:BX072550 (1) | 229061 nt | ||
| Polypeptide | UniProtKB:A0A8M2BKP3 (1) | 808 aa |
- Xin, Y., Guan, J., Li, Y., Duan, C. (2021) Regulation of cell quiescence-proliferation balance by Ca2+-CaMKK-Akt signaling. Journal of Cell Science. 134(20):
- Gupta, R.K., Wasilewska, I., Palchevska, O., Kuźnicki, J. (2020) Knockout of stim2a Increases Calcium Oscillations in Neurons and Induces Hyperactive-Like Phenotype in Zebrafish Larvae. International Journal of Molecular Sciences. 21(17):
- Wasilewska, I., Gupta, R.K., Wojtaś, B., Palchevska, O., Kuźnicki, J. (2020) stim2b Knockout Induces Hyperactivity and Susceptibility to Seizures in Zebrafish Larvae. Cells. 9(5):
- Pavez, M., Thompson, A.C., Arnott, H.J., Mitchell, C.B., D'Atri, I., Don, E.K., Chilton, J.K., Scott, E.K., Lin, J.Y., Young, K.M., Gasperini, R.J., Foa, L. (2019) STIM1 is required for remodelling of the endoplasmic reticulum and microtubule cytoskeleton in steering growth cones. The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(26):5095-5114
- Wasilewska, I., Gupta, R.K., Palchevska, O., Kuźnicki, J. (2019) Identification of Zebrafish Calcium Toolkit Genes and their Expression in the Brain. Genes. 10(3)
- Motiani, R.K., Tanwar, J., Raja, D.A., Vashisht, A., Khanna, S., Sharma, S., Srivastava, S., Sivasubbu, S., Natarajan, V.T., Gokhale, R.S. (2018) STIM1 activation of adenylyl cyclase 6 connects Ca2+ and cAMP signaling during melanogenesis.. The EMBO journal. 37(5)
- Tse, M.K., Hung, T.S., Chan, C.M., Wong, T., Dorothea, M., Leclerc, C., Moreau, M., Miller, A.L., Webb, S.E. (2018) Identification of Ca2+ signaling components in neural stem/progenitor cells during differentiation into neurons and glia in intact and dissociated zebrafish neurospheres.. Science China. Life sciences. 61(11):1352-1368
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
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