Gene
gatad2b
- ID
- ZDB-GENE-060503-655
- Name
- GATA zinc finger domain containing 2B
- Symbol
- gatad2b Nomenclature History
- Previous Names
-
- si:dkeyp-66g8.1
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Acts upstream of or within negative regulation of smoothened signaling pathway. Predicted to be located in nucleus. Predicted to be part of NuRD complex. Human ortholog(s) of this gene implicated in GAND syndrome. Orthologous to human GATAD2B (GATA zinc finger domain containing 2B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Lin et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| GAND syndrome | Alliance | GAND syndrome | 615074 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Transcriptional repressor p66 | Transcriptional repressor p66, coiled-coil MBD2-interaction domain | Zinc finger, GATA-type |
|---|---|---|---|---|---|
| UniProtKB:A0A8M1N9R4 | InterPro | 645 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gatad2b-201
(1)
|
Ensembl | 2,635 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-66G8 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044975 (1) | 1938 nt | ||
| Genomic | GenBank:CR388201 (1) | 67447 nt | ||
| Polypeptide | UniProtKB:A0A8M1N9R4 (1) | 645 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lin, C., Yao, E., Wang, K., Nozawa, Y., Shimizu, H., Johnson, J.R., Chen, J.N., Krogan, N.J., Chuang, P.T. (2014) Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling. Genes & Development. 28:2547-63
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