Gene
myo1g
- ID
- ZDB-GENE-060503-562
- Name
- myosin IG
- Symbol
- myo1g Nomenclature History
- Previous Names
-
- myosin 1g
- si:dkeyp-92c9.3 (2)
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within endosome organization and regulation of nodal signaling pathway. Predicted to be located in cell cortex and cell projection. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and plasma membrane. Orthologous to human MYO1G (myosin IG).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
nce18b | Allele with one deletion | Unknown | Premature Stop | CRISPR | |
nce18c | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
nce18e | Allele with one delins | Unknown | Unknown | CRISPR | |
sa14281 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa17276 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa43284 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa44915 | Allele with one point mutation | Unknown | Unknown | ENU |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR001609 | Myosin head, motor domain-like |
Domain | IPR010926 | Class I myosin tail homology domain |
Domain | IPR036072 | Class I myosin, motor domain |
Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | Class I myosin, motor domain | Class I myosin tail homology domain | Kinesin motor domain superfamily | Myosin head, motor domain-like | P-loop containing nucleoside triphosphate hydrolase |
---|---|---|---|---|---|---|---|
UniProtKB:A0A286YBP3 | InterPro | 1010 | |||||
UniProtKB:Q1LWT1 | InterPro | 998 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-154B15 | ZFIN Curated Data | |
Contained in | BAC | DKEYP-92C9 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001045221 (1) | 2997 nt | ||
Genomic | GenBank:BX530091 (1) | 180025 nt | ||
Polypeptide | UniProtKB:A0A286YBP3 (1) | 1010 aa |
- Kurup, A.J., Bailet, F., Fürthauer, M. (2024) Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry. Nature communications. 15:65476547
- Juan, T., Géminard, C., Coutelis, J.B., Cerezo, D., Polès, S., Noselli, S., Fürthauer, M. (2018) Myosin1D is an evolutionarily conserved regulator of animal left-right asymmetry. Nature communications. 9:1942
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
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