Gene
dyrk1b
- ID
- ZDB-GENE-060503-499
- Name
- dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
- Symbol
- dyrk1b Nomenclature History
- Previous Names
-
- si:ch211-225p5.1
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Acts upstream of or within endoderm formation. Predicted to be active in nucleus. Is expressed in head and somite. Human ortholog(s) of this gene implicated in abdominal obesity-metabolic syndrome 3. Orthologous to human DYRK1B (dual specificity tyrosine phosphorylation regulated kinase 1B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Mazmanian et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Mazmanian et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa44858 | Allele with one point mutation | Unknown | Unknown | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| abdominal obesity-metabolic syndrome 3 | Alliance | Abdominal obesity-metabolic syndrome 3 | 615812 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR044131 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain |
| Family | IPR050494 | Serine/threonine and dual-specificity kinase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine and dual-specificity kinase | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B4L1 | InterPro | 826 | ||||||
| UniProtKB:A0A0R4II39 | InterPro | 681 | ||||||
| UniProtKB:D1L3Y5 | InterPro | 751 | ||||||
| UniProtKB:A0A8M2B533 | InterPro | 833 | ||||||
| UniProtKB:A0A8M2B4K6 | InterPro | 758 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dyrk1b-201
(1)
|
Ensembl | 4,382 nt | ||
| mRNA |
dyrk1b-203
(1)
|
Ensembl | 3,933 nt | ||
| ncRNA |
dyrk1b-002
(1)
|
Ensembl | 918 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-225P5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-255N6 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001168265 (1) | 3933 nt | ||
| Genomic | GenBank:BX649388 (1) | 177865 nt | ||
| Polypeptide | UniProtKB:A0A8M2B533 (1) | 833 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Glenewinkel, F., Cohen, M.J., King, C.R., Kaspar, S., Bamberg-Lemper, S., Mymryk, J.S., Becker, W. (2016) The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2. Scientific Reports. 6:28241
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wang, B., Doan, D., Roman Petersen, Y., Alvarado, E., Alvarado, G., Bhandari, A., Mohanty, A., Mohanty, S., and Nissen, R.M. (2013) Wdr68 requires nuclear access for craniofacial development. PLoS One. 8(1):e54363
- Mazmanian, G., Kovshilovsky, M., Yen, D., Mohanty, A., Mohanty, S., Nee, A., and Nissen, R.M. (2010) The zebrafish dyrk1b gene is important for endoderm formation. Genesis (New York, N.Y. : 2000). 48(1):20-30
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